Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes

Yasushi Okamura, Atsuo Nishino, Yoshimichi Murata, Koichi Nakajo, Hirohide Iwasaki, Yukio Ohtsuka, Motoko Tanaka-Kunishima, Nobuyuki Takahashi, Yuji Hara, Takashi Yoshida, Motohiro Nishida, Haruo Okado, Hirofumi Watari, Ian A. Meinertzhagen, Nori Satoh, Kunitaro Takahashi, Yutaka Satou, Yasunobu Okada, Yasuo Mori

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

抄録

Ion fluxes through membrane ion channels play crucial roles both in neuronal signaling and the homeostatic control of body electrolytes. Despite our knowledge about the respective ion channels, just how diversification of ion channel genes underlies adaptation of animals to the physical environment remains unknown. Here we systematically survey up to 160 putative ion channel genes in the genome of Ciona intestinalis and compare them with corresponding gene sets from the genomes of the nematode Chaenorhabditis elegans, the fruit fly Drosophila melanogaster, and the more closely related genomes of vertebrates. Ciona has a set of so-called "prototype" genes for ion channels regulating neuronal excitability, or for neurotransmitter receptors, suggesting that genes responsible for neuronal signaling in mammals appear to have diversified mainly via gene duplications of the more restricted members of ancestral genomes before the ascidian/vertebrate divergence. Most genes responsible for modulation of neuronal excitability and pain sensation are absent from the ascidian genome, suggesting that these genes arose after the divergence of urochordates. In contrast, the divergent genes encoding connexins, transient receptor potential-related channels and chloride channels, channels involved rather in homeostatic control, indicate gene duplication events unique to the ascidian lineage. Because several invertebrate-unique channel genes exist in Ciona genome, the crown group of extant vertebrates not only acquired novel channel genes via gene/genome duplications but also discarded some ancient genes that have persisted in invertebrates. Such genome-wide information of ion channel genes in basal chordates enables us to begin correlating the innovation and remodeling of genes with the adaptation of more recent chordates to their physical environment.

元の言語英語
ページ(範囲)269-282
ページ数14
ジャーナルPhysiological Genomics
22
DOI
出版物ステータス出版済み - 10 1 2005

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Urochordata
Molecular Evolution
Ion Channels
Genome
Genes
Gene Duplication
Chordata
Vertebrates
Invertebrates
Ciona intestinalis
Transient Receptor Potential Channels
Chloride Channels
Neurotransmitter Receptor
Connexins
Drosophila melanogaster
Crowns
Diptera
Electrolytes
Mammals
Fruit

All Science Journal Classification (ASJC) codes

  • Physiology
  • Genetics

これを引用

Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes. / Okamura, Yasushi; Nishino, Atsuo; Murata, Yoshimichi; Nakajo, Koichi; Iwasaki, Hirohide; Ohtsuka, Yukio; Tanaka-Kunishima, Motoko; Takahashi, Nobuyuki; Hara, Yuji; Yoshida, Takashi; Nishida, Motohiro; Okado, Haruo; Watari, Hirofumi; Meinertzhagen, Ian A.; Satoh, Nori; Takahashi, Kunitaro; Satou, Yutaka; Okada, Yasunobu; Mori, Yasuo.

:: Physiological Genomics, 巻 22, 01.10.2005, p. 269-282.

研究成果: ジャーナルへの寄稿記事

Okamura, Y, Nishino, A, Murata, Y, Nakajo, K, Iwasaki, H, Ohtsuka, Y, Tanaka-Kunishima, M, Takahashi, N, Hara, Y, Yoshida, T, Nishida, M, Okado, H, Watari, H, Meinertzhagen, IA, Satoh, N, Takahashi, K, Satou, Y, Okada, Y & Mori, Y 2005, 'Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes', Physiological Genomics, 巻. 22, pp. 269-282. https://doi.org/10.1152/physiolgenomics.00229.2004
Okamura, Yasushi ; Nishino, Atsuo ; Murata, Yoshimichi ; Nakajo, Koichi ; Iwasaki, Hirohide ; Ohtsuka, Yukio ; Tanaka-Kunishima, Motoko ; Takahashi, Nobuyuki ; Hara, Yuji ; Yoshida, Takashi ; Nishida, Motohiro ; Okado, Haruo ; Watari, Hirofumi ; Meinertzhagen, Ian A. ; Satoh, Nori ; Takahashi, Kunitaro ; Satou, Yutaka ; Okada, Yasunobu ; Mori, Yasuo. / Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes. :: Physiological Genomics. 2005 ; 巻 22. pp. 269-282.
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abstract = "Ion fluxes through membrane ion channels play crucial roles both in neuronal signaling and the homeostatic control of body electrolytes. Despite our knowledge about the respective ion channels, just how diversification of ion channel genes underlies adaptation of animals to the physical environment remains unknown. Here we systematically survey up to 160 putative ion channel genes in the genome of Ciona intestinalis and compare them with corresponding gene sets from the genomes of the nematode Chaenorhabditis elegans, the fruit fly Drosophila melanogaster, and the more closely related genomes of vertebrates. Ciona has a set of so-called {"}prototype{"} genes for ion channels regulating neuronal excitability, or for neurotransmitter receptors, suggesting that genes responsible for neuronal signaling in mammals appear to have diversified mainly via gene duplications of the more restricted members of ancestral genomes before the ascidian/vertebrate divergence. Most genes responsible for modulation of neuronal excitability and pain sensation are absent from the ascidian genome, suggesting that these genes arose after the divergence of urochordates. In contrast, the divergent genes encoding connexins, transient receptor potential-related channels and chloride channels, channels involved rather in homeostatic control, indicate gene duplication events unique to the ascidian lineage. Because several invertebrate-unique channel genes exist in Ciona genome, the crown group of extant vertebrates not only acquired novel channel genes via gene/genome duplications but also discarded some ancient genes that have persisted in invertebrates. Such genome-wide information of ion channel genes in basal chordates enables us to begin correlating the innovation and remodeling of genes with the adaptation of more recent chordates to their physical environment.",
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AU - Watari, Hirofumi

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