Computer-aided classification of Alzheimer's disease based on support vector machine with combination of cerebral image features in MRI

C. Jongkreangkrai, Y. Vichianin, C. Tocharoenchai, H. Arimura

研究成果: Contribution to journalConference article査読

11 被引用数 (Scopus)

抄録

Several studies have differentiated Alzheimer's disease (AD) using cerebral image features derived from MR brain images. In this study, we were interested in combining hippocampus and amygdala volumes and entorhinal cortex thickness to improve the performance of AD differentiation. Thus, our objective was to investigate the useful features obtained from MRI for classification of AD patients using support vector machine (SVM). T1-weighted MR brain images of 100 AD patients and 100 normal subjects were processed using FreeSurfer software to measure hippocampus and amygdala volumes and entorhinal cortex thicknesses in both brain hemispheres. Relative volumes of hippocampus and amygdala were calculated to correct variation in individual head size. SVM was employed with five combinations of features (H: hippocampus relative volumes, A: amygdala relative volumes, E: entorhinal cortex thicknesses, HA: hippocampus and amygdala relative volumes and ALL: all features). Receiver operating characteristic (ROC) analysis was used to evaluate the method. AUC values of five combinations were 0.8575 (H), 0.8374 (A), 0.8422 (E), 0.8631 (HA) and 0.8906 (ALL). Although "ALL" provided the highest AUC, there were no statistically significant differences among them except for "A" feature. Our results showed that all suggested features may be feasible for computer-aided classification of AD patients.

本文言語英語
論文番号012036
ジャーナルJournal of Physics: Conference Series
694
1
DOI
出版ステータス出版済み - 3 24 2016
イベント13th South-East Asian Congress of Medical Physics, SEACOMP 2015 - Yogyakarta, インドネシア
継続期間: 12 10 201512 12 2015

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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