Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique

Yasuo Yamashita, Hidetaka Arimura, Takashi Yoshiura, Chiaki Tokunaga, Taiki Magome, Akira Monji, Tomoyuki Noguchi, Fukai Toyofuku, Masafumi Oki, Yasuhiko Nakamura, Hiroshi Honda

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

Arterial spin labeling (ASL) is one of promising non-invasive magnetic resonance (MR) imaging techniques for diagnosis of Alzheimer's disease (AD) by measuring cerebral blood flow (CBF). The aim of this study was to develop a computer-aided classification system for AD patients based on CBFs measured by the ASL technique. The average CBFs in cortical regions were determined as functional image features based on the CBF map image, which was non-linearly transformed to a Talairach brain atlas by using a free-form deformation. An artificial neural network (ANN) was trained with the CBF functional features in 10 cortical regions, and was employed for distinguishing patients with AD from control subjects. For evaluation of the method, we applied the proposed method to 20 cases including ten AD patients and ten control subjects, who were scanned at a 3.0-Tesla MR unit. As a result, the area under the receiver operating characteristic curve obtained by the proposed method was 0.893 based on a leave-one-out-by-case test in identification of AD cases among 20 cases. The proposed method would be feasible for classification of patients with AD.

本文言語英語
ホスト出版物のタイトルMedical Imaging 2010
ホスト出版物のサブタイトルComputer-Aided Diagnosis
編集者Ronald M. Summers, Nico Karssemeijer
出版社SPIE
ISBN(電子版)9780819480255
DOI
出版ステータス出版済み - 2010
イベントMedical Imaging 2010: Computer-Aided Diagnosis - San Diego, 米国
継続期間: 2月 16 20102月 18 2010

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
7624
ISSN(印刷版)1605-7422

その他

その他Medical Imaging 2010: Computer-Aided Diagnosis
国/地域米国
CitySan Diego
Period2/16/102/18/10

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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