Concerted regulation of gonad differentiation by transcription factors and growth factors

Taiga Suzuki, Hirofumi Mizusaki, Ken Kawabe, Megumi Kasahara, Hidefumi Yoshioka, Ken Ichirou Morohashi

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the genes underlying human diseases displaying gonadal defects and as the genes necessary for gonad differentiation as demonstrated by gene disruption studies. In addition, one of the growth factors, WNT4, is known to be involved in gonadal differentiation. However, it remains unclear which gene is directly downstream of the WNT4 signal. We have recently demonstrated that Dax1 (NR0B1) gene transcription is significantly up-regulated by the presence of SF1 (NR5A1). Functional analysis showed that DAX1 acts as a repressor against SF1 through direct interaction between the repeated sequences at the N-terminus of DAX1 and a ligand-binding domain of SF1. Considering that the expressions of these factors during gonad differentiation show a sexually dimorphic pattern, it is likely that the Dax1 gene transcription is up-regulated by WNT4 signal and thereafter DAX1 suppresses the genes downstream of SF1 such as Amb and steroidogenic genes in female gonads.

元の言語英語
ページ(範囲)68-78
ページ数11
ジャーナルNovartis Foundation symposium
244
出版物ステータス出版済み - 12 1 2002

Fingerprint

Gonads
Intercellular Signaling Peptides and Proteins
Transcription Factors
Genes
Ligands

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Concerted regulation of gonad differentiation by transcription factors and growth factors. / Suzuki, Taiga; Mizusaki, Hirofumi; Kawabe, Ken; Kasahara, Megumi; Yoshioka, Hidefumi; Morohashi, Ken Ichirou.

:: Novartis Foundation symposium, 巻 244, 01.12.2002, p. 68-78.

研究成果: ジャーナルへの寄稿記事

Suzuki, T, Mizusaki, H, Kawabe, K, Kasahara, M, Yoshioka, H & Morohashi, KI 2002, 'Concerted regulation of gonad differentiation by transcription factors and growth factors', Novartis Foundation symposium, 巻. 244, pp. 68-78.
Suzuki, Taiga ; Mizusaki, Hirofumi ; Kawabe, Ken ; Kasahara, Megumi ; Yoshioka, Hidefumi ; Morohashi, Ken Ichirou. / Concerted regulation of gonad differentiation by transcription factors and growth factors. :: Novartis Foundation symposium. 2002 ; 巻 244. pp. 68-78.
@article{ccdbcae1c25b4b94a1777ff4ababf733,
title = "Concerted regulation of gonad differentiation by transcription factors and growth factors",
abstract = "It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the genes underlying human diseases displaying gonadal defects and as the genes necessary for gonad differentiation as demonstrated by gene disruption studies. In addition, one of the growth factors, WNT4, is known to be involved in gonadal differentiation. However, it remains unclear which gene is directly downstream of the WNT4 signal. We have recently demonstrated that Dax1 (NR0B1) gene transcription is significantly up-regulated by the presence of SF1 (NR5A1). Functional analysis showed that DAX1 acts as a repressor against SF1 through direct interaction between the repeated sequences at the N-terminus of DAX1 and a ligand-binding domain of SF1. Considering that the expressions of these factors during gonad differentiation show a sexually dimorphic pattern, it is likely that the Dax1 gene transcription is up-regulated by WNT4 signal and thereafter DAX1 suppresses the genes downstream of SF1 such as Amb and steroidogenic genes in female gonads.",
author = "Taiga Suzuki and Hirofumi Mizusaki and Ken Kawabe and Megumi Kasahara and Hidefumi Yoshioka and Morohashi, {Ken Ichirou}",
year = "2002",
month = "12",
day = "1",
language = "English",
volume = "244",
pages = "68--78",
journal = "Novartis Foundation Symposium",
issn = "1528-2511",
publisher = "Novartis Foundation",

}

TY - JOUR

T1 - Concerted regulation of gonad differentiation by transcription factors and growth factors

AU - Suzuki, Taiga

AU - Mizusaki, Hirofumi

AU - Kawabe, Ken

AU - Kasahara, Megumi

AU - Yoshioka, Hidefumi

AU - Morohashi, Ken Ichirou

PY - 2002/12/1

Y1 - 2002/12/1

N2 - It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the genes underlying human diseases displaying gonadal defects and as the genes necessary for gonad differentiation as demonstrated by gene disruption studies. In addition, one of the growth factors, WNT4, is known to be involved in gonadal differentiation. However, it remains unclear which gene is directly downstream of the WNT4 signal. We have recently demonstrated that Dax1 (NR0B1) gene transcription is significantly up-regulated by the presence of SF1 (NR5A1). Functional analysis showed that DAX1 acts as a repressor against SF1 through direct interaction between the repeated sequences at the N-terminus of DAX1 and a ligand-binding domain of SF1. Considering that the expressions of these factors during gonad differentiation show a sexually dimorphic pattern, it is likely that the Dax1 gene transcription is up-regulated by WNT4 signal and thereafter DAX1 suppresses the genes downstream of SF1 such as Amb and steroidogenic genes in female gonads.

AB - It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the genes underlying human diseases displaying gonadal defects and as the genes necessary for gonad differentiation as demonstrated by gene disruption studies. In addition, one of the growth factors, WNT4, is known to be involved in gonadal differentiation. However, it remains unclear which gene is directly downstream of the WNT4 signal. We have recently demonstrated that Dax1 (NR0B1) gene transcription is significantly up-regulated by the presence of SF1 (NR5A1). Functional analysis showed that DAX1 acts as a repressor against SF1 through direct interaction between the repeated sequences at the N-terminus of DAX1 and a ligand-binding domain of SF1. Considering that the expressions of these factors during gonad differentiation show a sexually dimorphic pattern, it is likely that the Dax1 gene transcription is up-regulated by WNT4 signal and thereafter DAX1 suppresses the genes downstream of SF1 such as Amb and steroidogenic genes in female gonads.

UR - http://www.scopus.com/inward/record.url?scp=0036359161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036359161&partnerID=8YFLogxK

M3 - Article

C2 - 11990799

AN - SCOPUS:0036359161

VL - 244

SP - 68

EP - 78

JO - Novartis Foundation Symposium

JF - Novartis Foundation Symposium

SN - 1528-2511

ER -