Concordance for neuroblastoma in monozygotic twins: Case report and review of the literature

Tatsuro Tajiri, Ryota Sozaki, Yoshiaki Kinoshita, Sakura Tanaka, Yuhki Koga, Aiko Suminoe, Toshiro Hara, Kenichi Kohashi, Yoshinao Oda, Kouji Masumoto, Miki Ohira, Akira Nakagawara, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)


The patients were infant male twins born by cesarean delivery following a healthy pregnancy at 36 weeks' gestation to unrelated parents. At 4 months of age, twin 2 presented with hepatomegaly and a right suprarenal mass. Resection of an adrenal tumor and a liver tumor biopsy were performed. Twin 1 had no symptoms at 4 months of age. Screening by abdominal ultrasonography showed multiple masses in the liver but no adrenal mass. Metaiodobenzylguanidine scintigraphy showed positive findings in multiple liver masses. A laparoscopic biopsy for a liver tumor was performed. All primary tumor and liver tumor specimens from twin 2 and the liver tumor of twin 1 had the same histologic classification of neuroblastoma and nearly identical genetic aberrations, including a chromosome gain or loss using array-comparative genomic hybridization. From these clinical and pathologic findings and genetic analyses, we strongly demonstrate the transplacental metastatic spread from twin 2 to twin 1. In the literature, 9 pairs of concordant twin neuroblastomas, including the current twin, have been presented; and the clinical findings of 5 twin pairs may represent placental metastases from one twin with congenital neuroblastoma to the other twin. This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations.

ジャーナルJournal of Pediatric Surgery
出版ステータス出版済み - 12月 2010

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科


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