Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

E. Azuma, S. Kojima, K. Kato, T. Matsuyama, Y. Yamada, N. Kondo, H. Sawada, M. Hanada, T. Shibata, N. Tabata, M. Watanabe, Y. Shimono, T. Deguchi, M. Umemoto, M. Higashikawa, H. Kawasaki, Y. Komada, M. Sakurai

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.

本文言語英語
ページ(範囲)1085-1087
ページ数3
ジャーナルBone Marrow Transplantation
19
11
DOI
出版ステータス出版済み - 6 1 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学
  • 移植

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