Connecting threads: Epigenetics and metabolism

Sayako Katada, Axel Imhof, Paolo Sassone-Corsi

研究成果: ジャーナルへの寄稿小調査

172 引用 (Scopus)

抜粋

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable patterns of gene expression. The challenge will now be to understand how localized fluctuations in levels of metabolites control chromatin modifiers in space and time, translating a dynamic metabolic state into a histone map.

元の言語英語
ページ(範囲)24-28
ページ数5
ジャーナルCell
148
発行部数1-2
DOI
出版物ステータス出版済み - 1 20 2012
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

フィンガープリント Connecting threads: Epigenetics and metabolism' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用