Connecting threads: Epigenetics and metabolism

Sayako Katada, Axel Imhof, Paolo Sassone-Corsi

研究成果: Contribution to journalShort survey査読

185 被引用数 (Scopus)

抄録

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable patterns of gene expression. The challenge will now be to understand how localized fluctuations in levels of metabolites control chromatin modifiers in space and time, translating a dynamic metabolic state into a histone map.

本文言語英語
ページ(範囲)24-28
ページ数5
ジャーナルCell
148
1-2
DOI
出版ステータス出版済み - 1 20 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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