Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus

Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi

研究成果: ジャーナルへの寄稿学術誌査読

29 被引用数 (Scopus)

抄録

A ganglioside molecular species SJG-1 has been obtained from the n- hexane soluble lipid fraction of the chloroform/ methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N- glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.

本文言語英語
ページ(範囲)3171-3174
ページ数4
ジャーナルEuropean Journal of Organic Chemistry
11
DOI
出版ステータス出版済み - 11月 1999

!!!All Science Journal Classification (ASJC) codes

  • 物理化学および理論化学
  • 有機化学

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