Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

Koji Yamada, Yasuo Harada, Tomofumi Miyamoto, Ryuichi Isobi, Ryuichi Higuchi

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

抄録

A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of I was determined, and the major component was 1-O-[α-L- fucopyranosyl-(1→4)-(N-acetyl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D- neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D- glucopyranosyl]-(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanylamino]-14-methyl- hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.

元の言語英語
ページ(範囲)157-159
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
48
発行部数1
DOI
出版物ステータス出版済み - 1 2000

Fingerprint

Holothuria
Sea Cucumbers
Gangliosides
PC12 Cells
Chloroform
Methanol
Rats
Cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax. / Yamada, Koji; Harada, Yasuo; Miyamoto, Tomofumi; Isobi, Ryuichi; Higuchi, Ryuichi.

:: Chemical and Pharmaceutical Bulletin, 巻 48, 番号 1, 01.2000, p. 157-159.

研究成果: ジャーナルへの寄稿記事

@article{d993b77006b54a1798220761f08a8e21,
title = "Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax",
abstract = "A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of I was determined, and the major component was 1-O-[α-L- fucopyranosyl-(1→4)-(N-acetyl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D- neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D- glucopyranosyl]-(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanylamino]-14-methyl- hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.",
author = "Koji Yamada and Yasuo Harada and Tomofumi Miyamoto and Ryuichi Isobi and Ryuichi Higuchi",
year = "2000",
month = "1",
doi = "10.1248/cpb.48.157",
language = "English",
volume = "48",
pages = "157--159",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "The Pharmaceutical Society of Japan",
number = "1",

}

TY - JOUR

T1 - Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

AU - Yamada, Koji

AU - Harada, Yasuo

AU - Miyamoto, Tomofumi

AU - Isobi, Ryuichi

AU - Higuchi, Ryuichi

PY - 2000/1

Y1 - 2000/1

N2 - A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of I was determined, and the major component was 1-O-[α-L- fucopyranosyl-(1→4)-(N-acetyl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D- neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D- glucopyranosyl]-(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanylamino]-14-methyl- hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.

AB - A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of I was determined, and the major component was 1-O-[α-L- fucopyranosyl-(1→4)-(N-acetyl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D- neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D- glucopyranosyl]-(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanylamino]-14-methyl- hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.

UR - http://www.scopus.com/inward/record.url?scp=0033964890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033964890&partnerID=8YFLogxK

U2 - 10.1248/cpb.48.157

DO - 10.1248/cpb.48.157

M3 - Article

C2 - 10705496

AN - SCOPUS:0033964890

VL - 48

SP - 157

EP - 159

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 1

ER -