Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image

Tomoshige Shimomura, Kugler Mauricio, Tatsuya Yokota, Chika Iwamoto, Kenoki Ouchida, Makoto Hashizume, Hidekata Hontani

研究成果: 著書/レポートタイプへの貢献会議での発言

1 引用 (Scopus)

抄録

In this paper, we propose a method for constructing a multi-scale model of pancreas tumor of a KrasLSL.G12D/+; p53R172H/+; PdxCretg/+ (KPC) mouse that is a genetically engineered mouse model of pancreas tumor. The model represents the correlation between the value at each voxel in the MRI image of the tumor and the pathology image patches that are observed at each portion corresponds to the location of the voxel in the MRI image. The model is represented by a cascade of image generators trained by a Laplacian Pyramid of Generative Adversarial Network (LAPGAN). When some voxel in a pancreas tumor region in an MRI image is selected, the cascade of generators outputs patches of the pathology images that can be observed at the location corresponds to the selected voxel. We trained the generators by using an MRI image and a 3D pathology image, the latter was first reconstructed from a spatial series of the 2D pathology images and was then registered to the MRI image.

元の言語英語
ホスト出版物のタイトルComputational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings
編集者Zeike Taylor, Hrvoje Bogunovic, David Snead, Mona K. Garvin, Xin Jan Chen, Francesco Ciompi, Yanwu Xu, Lena Maier-Hein, Mitko Veta, Emanuele Trucco, Danail Stoyanov, Nasir Rajpoot, Jeroen van der Laak, Anne Martel, Stephen McKenna
出版者Springer Verlag
ページ27-34
ページ数8
ISBN(印刷物)9783030009489
DOI
出版物ステータス出版済み - 1 1 2018
イベント1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018 - Granada, スペイン
継続期間: 9 16 20189 20 2018

出版物シリーズ

名前Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
11039 LNCS
ISSN(印刷物)0302-9743
ISSN(電子版)1611-3349

その他

その他1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018
スペイン
Granada
期間9/16/189/20/18

Fingerprint

Generative Models
Voxel
Pathology
Magnetic resonance imaging
Tumors
Tumor
Generator
Cascade
Patch
Mouse
Multiscale Model
Pyramid
3D Image
Model
Series
Output

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

これを引用

Shimomura, T., Mauricio, K., Yokota, T., Iwamoto, C., Ouchida, K., Hashizume, M., & Hontani, H. (2018). Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image. : Z. Taylor, H. Bogunovic, D. Snead, M. K. Garvin, X. J. Chen, F. Ciompi, Y. Xu, L. Maier-Hein, M. Veta, E. Trucco, D. Stoyanov, N. Rajpoot, J. van der Laak, A. Martel, ... S. McKenna (版), Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings (pp. 27-34). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 11039 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-00949-6_4

Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image. / Shimomura, Tomoshige; Mauricio, Kugler; Yokota, Tatsuya; Iwamoto, Chika; Ouchida, Kenoki; Hashizume, Makoto; Hontani, Hidekata.

Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. 版 / Zeike Taylor; Hrvoje Bogunovic; David Snead; Mona K. Garvin; Xin Jan Chen; Francesco Ciompi; Yanwu Xu; Lena Maier-Hein; Mitko Veta; Emanuele Trucco; Danail Stoyanov; Nasir Rajpoot; Jeroen van der Laak; Anne Martel; Stephen McKenna. Springer Verlag, 2018. p. 27-34 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻 11039 LNCS).

研究成果: 著書/レポートタイプへの貢献会議での発言

Shimomura, T, Mauricio, K, Yokota, T, Iwamoto, C, Ouchida, K, Hashizume, M & Hontani, H 2018, Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image. : Z Taylor, H Bogunovic, D Snead, MK Garvin, XJ Chen, F Ciompi, Y Xu, L Maier-Hein, M Veta, E Trucco, D Stoyanov, N Rajpoot, J van der Laak, A Martel & S McKenna (版), Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 巻. 11039 LNCS, Springer Verlag, pp. 27-34, 1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018, Granada, スペイン, 9/16/18. https://doi.org/10.1007/978-3-030-00949-6_4
Shimomura T, Mauricio K, Yokota T, Iwamoto C, Ouchida K, Hashizume M その他. Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image. : Taylor Z, Bogunovic H, Snead D, Garvin MK, Chen XJ, Ciompi F, Xu Y, Maier-Hein L, Veta M, Trucco E, Stoyanov D, Rajpoot N, van der Laak J, Martel A, McKenna S, 編集者, Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. Springer Verlag. 2018. p. 27-34. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-030-00949-6_4
Shimomura, Tomoshige ; Mauricio, Kugler ; Yokota, Tatsuya ; Iwamoto, Chika ; Ouchida, Kenoki ; Hashizume, Makoto ; Hontani, Hidekata. / Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image. Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. 編集者 / Zeike Taylor ; Hrvoje Bogunovic ; David Snead ; Mona K. Garvin ; Xin Jan Chen ; Francesco Ciompi ; Yanwu Xu ; Lena Maier-Hein ; Mitko Veta ; Emanuele Trucco ; Danail Stoyanov ; Nasir Rajpoot ; Jeroen van der Laak ; Anne Martel ; Stephen McKenna. Springer Verlag, 2018. pp. 27-34 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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