Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject in biotechnology and also in bottom-up nanotechnology. To mimick formation of spherical viruses and clathrin, we have reported design of a C3-symmetric peptide conjugate bearing three β-sheet forming peptides (Trigonal-FKFE) and their self-assembly into nanospheres in acidic solutions. Here we report a novel C3-symmetric peptide conjugate (Wheel-FKFE) which have wheel-like arrangement. The Wheel-FKFE self-assembled into nanofibers with uniform width (3 nm) in neutral aqueous solutions. Furthermore, we developed a simpler trigonal conjugate bearing glutathione as self-assembly units (Trigonal-glutathione). The conjugate self-assembled into nanocapsules with the size of about 300 nm in aqueous solutions.
|出版物ステータス||出版済み - 12 1 2006|
|イベント||55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本|
継続期間: 9 20 2006 → 9 22 2006
|その他||55th Society of Polymer Science Japan Symposium on Macromolecules|
|期間||9/20/06 → 9/22/06|
All Science Journal Classification (ASJC) codes