Construction of nonlinear response systems utilizing molecular machines

Masato Ikeda, Masayuki Takeuchi, Seiji Shinkai

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Construction of nonlinear response systems is of importance for switching and amplification of guest affinity and selectivity. In nature the phenomena are ubiquitous, however, the methodology for the design of such artificial systems has not been developed so far. In nonlinear response systems, the guest binding information must be efficiently transmitted to the other binding sites through the positive homotropic allosteric interaction. Here, we show a new concept utilizing a molecular machinery approach to realize the nonlinear response. In our scheme, rotating modules are used for the allosteric interaction, where the guest binding information in a binding site is passed to the other binding sites in unison through "rotation". With this concept, we rationally designed a variety of double decker porphyrin host molecules as well as the other host molecules bearing rotational axle. These studies open up a new field for designing intelligent molecular machinery systems which can respond to outer stimuli.

元の言語英語
ページ(範囲)1201-1209
ページ数9
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
60
発行部数12
DOI
出版物ステータス出版済み - 1 1 2002

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Binding Sites
Machinery
Bearings (structural)
Molecules
Porphyrins
Axles
Amplification

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

これを引用

Construction of nonlinear response systems utilizing molecular machines. / Ikeda, Masato; Takeuchi, Masayuki; Shinkai, Seiji.

:: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 巻 60, 番号 12, 01.01.2002, p. 1201-1209.

研究成果: ジャーナルへの寄稿記事

Ikeda, Masato ; Takeuchi, Masayuki ; Shinkai, Seiji. / Construction of nonlinear response systems utilizing molecular machines. :: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2002 ; 巻 60, 番号 12. pp. 1201-1209.
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