Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury

Masayuki Miyazaki, Masaki Kato, Masatake Tanaka, Kosuke Tanaka, Shinichiro Takao, Motoyuki Kohjima, Tetsuhide Ito, Munechika Enjoji, Makoto Nakamuta, Kazuhiro Kotoh, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background and Aims: Disturbances in hepatic microcirculation are believed to be involved in the mechanisms regulating the progression of acute liver injury (ALI). Evaluation of hepatic hemodynamics in patients with acute liver injury might be helpful in understanding the extent of the intrahepatic microcirculatory disturbances. Therefore, we investigated whether contrast-enhanced ultrasonography (CEUS) is useful to evaluate the changes in hepatic hemodynamics in patients with ALI. Methods: CEUS was performed in 21 patients with ALI and coagulopathy. Participants were injected with 0.0075mL Sonazoid/kg body weight, and time-intensity curves were simultaneously recorded for the hepatic and portal veins. The data were compared with those of 10 healthy volunteers. Results: The arrival time of Sonazoid in the hepatic vein was similar to that in the portal vein in the patients, whereas the arrival time in the hepatic vein was delayed relative to that in the portal vain in the controls (interval between the hepatic and portal vein arrival times, control vs patients 6.74±3.07s vs 1.13±1.07s, P<0.001). Repeated examination revealed that the interval between the hepatic and portal vein arrival times was extended by improvements in hepatic function. The early arrival of Sonazoid in the hepatic vein in the patients is likely to reflect the formation of intrahepatic shunts as a result of hepatic microcirculatory disturbances. Conclusion: CEUS using Sonazoid is a useful method to estimate the changes in hepatic hemodynamics in patients with ALI.

元の言語英語
ページ(範囲)1749-1756
ページ数8
ジャーナルJournal of Gastroenterology and Hepatology (Australia)
26
発行部数12
DOI
出版物ステータス出版済み - 1 1 2011

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Ultrasonography
Hemodynamics
Hepatic Veins
Liver
Wounds and Injuries
Portal Vein
Sonazoid
Microcirculation
Healthy Volunteers
Body Weight

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

これを引用

Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury. / Miyazaki, Masayuki; Kato, Masaki; Tanaka, Masatake; Tanaka, Kosuke; Takao, Shinichiro; Kohjima, Motoyuki; Ito, Tetsuhide; Enjoji, Munechika; Nakamuta, Makoto; Kotoh, Kazuhiro; Takayanagi, Ryoichi.

:: Journal of Gastroenterology and Hepatology (Australia), 巻 26, 番号 12, 01.01.2011, p. 1749-1756.

研究成果: ジャーナルへの寄稿記事

Miyazaki, Masayuki ; Kato, Masaki ; Tanaka, Masatake ; Tanaka, Kosuke ; Takao, Shinichiro ; Kohjima, Motoyuki ; Ito, Tetsuhide ; Enjoji, Munechika ; Nakamuta, Makoto ; Kotoh, Kazuhiro ; Takayanagi, Ryoichi. / Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury. :: Journal of Gastroenterology and Hepatology (Australia). 2011 ; 巻 26, 番号 12. pp. 1749-1756.
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AU - Kato, Masaki

AU - Tanaka, Masatake

AU - Tanaka, Kosuke

AU - Takao, Shinichiro

AU - Kohjima, Motoyuki

AU - Ito, Tetsuhide

AU - Enjoji, Munechika

AU - Nakamuta, Makoto

AU - Kotoh, Kazuhiro

AU - Takayanagi, Ryoichi

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