Contributing factors in the pathogenesis of acquired cholesteatoma: Size analysis based on MDCT

Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Dashjamts Tuvshinjargal, Hironori Kamano, Hideki Shiratsuchi, Hiroshi Honda

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

OBJECTIVE. The purpose of this article is to explore the factors that contribute to the occurrence of cholesteatoma. We studied the size of the mastoid air cells and the tympanic cavity using high-resolution CT. MATERIALS AND METHODS. Temporal bone CT scans of consecutive patients with unilateral cholesteatoma and healthy control subjects were retrospectively analyzed. We compared the total volume and the greatest cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity between the affected and unaffected sides in patients with cholesteatoma and in the control subjects. We also compared separately the measured volumes of the cavities of the mastoid air cells and tympanic cavity between the unaffected side of the patients with cholesteatoma and the control subjects. RESULTS. One hundred temporal bones of 50 patients with cholesteatoma and 50 control subjects were included. Both the volume and the cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity in the affected side of the patients with cholesteatoma were significantly smaller than those in the unaffected side (p < 0.001). Moreover, both the volume and the cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity in both affected and unaffected sides of patients with cholesteatoma were significantly smaller than those in control subjects (p < 0.001). The volume of the cavities of the mastoid air cells in the unaffected side of patients with cholesteatoma was smaller than that of the control subjects (p < 0.001). In contrast, no significant difference was found in the tympanic cavity volume between the unaffected side and the control subjects. CONCLUSION. Our results were consistent with the hypothesized contribution of mastoid air cell underdevelopment to the occurrence of cholesteatoma. A small tympanic cavity is less likely to contribute to the occurrence of cholesteatoma.

本文言語英語
ページ(範囲)1172-1175
ページ数4
ジャーナルAmerican Journal of Roentgenology
196
5
DOI
出版ステータス出版済み - 5 2011

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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