Contribution of glutamate receptors to benzodiazepine withdrawal signs

Tsuda Makoto, Norifumi Shimizu, Tsutomu Suzuki

研究成果: Contribution to journalReview article

10 引用 (Scopus)

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Recent research has demonstrated that the receptor for glutamate, a major excitatory neurotransmitter, may play an important role in the expression of benzodiazepine withdrawal signs. This proposal is based on various observations. For example, antagonists for N-methyl-D-aspartate (NMDA), non-NMDA and metabotropic glutamate (mGlu) receptors can suppress the behavioral signs of benzodiazepine withdrawal in mice and rats. Furthermore, the NMDA receptor in the cerebrocortical area of diazepam-withdrawn rats is upregulated. Finally, the stimulation of phosphoinositide hydrolysis mediated by mGluR is enhanced in cerebrocortical slices from lorazepam-withdrawn mice. These findings show that the upregulation of signal transduction mediated by glutamate receptors during diazepam withdrawal plays a role in the neuroadaptive response responsible for the expression of diazepam withdrawal signs. Furthermore, ligands for glutamate receptors may be suitable targets for treating benzodiazepine withdrawal signs.

元の言語英語
ページ(範囲)1-6
ページ数6
ジャーナルJapanese Journal of Pharmacology
81
発行部数1
DOI
出版物ステータス出版済み - 10 23 1999
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Molecular Medicine

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