Control of cardiovascular differentiation by microRNAs

Kisho Ohtani, Stefanie Dimmeler

研究成果: Contribution to journalReview article査読

95 被引用数 (Scopus)

抄録

MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.

本文言語英語
ページ(範囲)5-11
ページ数7
ジャーナルBasic Research in Cardiology
106
1
DOI
出版ステータス出版済み - 1 1 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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