TY - JOUR
T1 - Control of cardiovascular differentiation by microRNAs
AU - Ohtani, Kisho
AU - Dimmeler, Stefanie
PY - 2011/1/1
Y1 - 2011/1/1
N2 - MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.
AB - MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.
UR - http://www.scopus.com/inward/record.url?scp=79151481024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79151481024&partnerID=8YFLogxK
U2 - 10.1007/s00395-010-0139-7
DO - 10.1007/s00395-010-0139-7
M3 - Review article
C2 - 21184089
AN - SCOPUS:79151481024
VL - 106
SP - 5
EP - 11
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
SN - 0300-8428
IS - 1
ER -