Control of vascular endothelial cell function by changing the pore size of self-organized porous films

Emiko Itoh, Aiko Takayama, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Simomura

研究成果: 会議への寄与タイプ論文

抄録

Self-organized porous films (honeycomb films) with different pore size were prepared in order to investigate the influence of pore size on porcine arterial endothelial cells (PAECs) behavior. These films were fabricated by applying a moist air to a spread polymer solution containing biodegradable polymers (poly (ε-caprolactone)(PCL)) and an amphiphilic polymer. Four different pore sizes (5,10,12,16 μm) were prepared. Changes in cell morphology, proliferation, cytoskeleton and extra cellular matrix (ECM) (fibronectin, laminin, type IV collagen, elastin) production profiles were observed by optical, fluorescence, and scanning electron microscopy. The degree of spreading of PAECs was enhanced with increase of the pore size. PAECs proliferated on the honeycomb films. Almost the same ECM production profiles were obtained on the honeycomb films. These suggest that the honeycomb film is suitable as a material of a new vascular device.

元の言語英語
ページ数1
出版物ステータス出版済み - 12 1 2005
イベント54th SPSJ Annual Meeting 2005 - Yokohama, 日本
継続期間: 5 25 20055 27 2005

その他

その他54th SPSJ Annual Meeting 2005
日本
Yokohama
期間5/25/055/27/05

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Honeycomb structures
Tissue culture
Endothelial cells
Biodegradation
Tissue engineering
Collagen
Pore size
Porous materials
Fluorescence
Scanning electron microscopy
Polymers
Elastin
Biodegradable polymers
Polymer solutions
Air

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Itoh, E., Takayama, A., Tanaka, M., Yamamoto, S., & Simomura, M. (2005). Control of vascular endothelial cell function by changing the pore size of self-organized porous films. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本.

Control of vascular endothelial cell function by changing the pore size of self-organized porous films. / Itoh, Emiko; Takayama, Aiko; Tanaka, Masaru; Yamamoto, Sadaaki; Simomura, Masatsugu.

2005. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本.

研究成果: 会議への寄与タイプ論文

Itoh, E, Takayama, A, Tanaka, M, Yamamoto, S & Simomura, M 2005, 'Control of vascular endothelial cell function by changing the pore size of self-organized porous films' 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本, 5/25/05 - 5/27/05, .
Itoh E, Takayama A, Tanaka M, Yamamoto S, Simomura M. Control of vascular endothelial cell function by changing the pore size of self-organized porous films. 2005. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本.
Itoh, Emiko ; Takayama, Aiko ; Tanaka, Masaru ; Yamamoto, Sadaaki ; Simomura, Masatsugu. / Control of vascular endothelial cell function by changing the pore size of self-organized porous films. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, 日本.1 p.
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