Controling the rate of protein release from polyelectrolyte complexes

Noriho Kamiya, Alexander M. Klibanov

研究成果: ジャーナルへの寄稿学術誌査読

43 被引用数 (Scopus)

抄録

Extended protein release from readily prepared, water-insoluble complexes with oppositely charged polyions is explored. Using hen egg-white lysozyme as a model, its sustained release from such complexes with a number of polyanions under physiological conditions has been demonstrated and rationalized. The rate of release varies orders of magnitude and is controlled by the nature of the polyanion (decreasing upon increase in its linear charge density, length, and hydrophobicity) and the complex particle size (the larger the particles, the slower the release).

本文言語英語
ページ(範囲)590-594
ページ数5
ジャーナルBiotechnology and Bioengineering
82
5
DOI
出版ステータス出版済み - 6月 5 2003

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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