Controlled release of clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects

Ali Alenezi, Yoshihito Naito, Takayuki Terukina, Widyasri Prananingrum, Yohei Jinno, Tatsuaki Tagami, Tetsuya Ozeki, Silvia Galli, Ryo Jimbo

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

This study evaluated the sustained release effect of clarithromycin-loaded in PLGA microspheres in a rabbit calvaria defect model. Four bone defects (ø5.0) were created in the calvaria of New Zealand White rabbits (n = 21, n = 7/time point). The defects were randomly designated to four groups. Group 1: No augmentation (sham), Group 2: beta-tricalcium phosphate (β-TCP), Group 3: β-TCP with 0.12 µg clarithromycin, and Group 4: β-TCP with 6.12 µg PLGA microspheres loaded with 0.12 µg Clarithromycin. After 2, 4, and 12 weeks of healing, bone regeneration was evaluated using micro-computed tomography (µCT) and histology. Clarithromycin release from PLGA microspheres revealed sustained release for around 4 weeks with ∼50% release during the first week. Histologically, new bone formation was evident at 2 and 4 weeks of healing in all groups and bone formation increased as a function of healing time. At 12 weeks, Group 4 showed significantly higher amount of newly formed bone compared to Group 1. The µCT showed that Group 4 expressed significantly higher bone formation compared to Group 1 at all time points. The in vivo findings showed that β-TCP with clarithromycin-loaded microspheres can enhance bone formation in bone defects.

本文言語英語
ページ(範囲)201-208
ページ数8
ジャーナルJournal of Biomedical Materials Research - Part B Applied Biomaterials
106
1
DOI
出版ステータス出版済み - 1 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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