Controlled stability of the triple-stranded helical structure of a β-1,3-glucan with a chromophoric aromatic moiety at a peripheral position

Masato Ikeda, Shuichi Haraguchi, Munenori Numata, Seiji Shinkai

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

We synthesized a semiartificial β-1,3-glucan, curdlan with dialkylaniline groups (CUR-DA), that bears chromophoric aromatic groups at its peripheral positions. Spectroscopic studies as well as microscopic observations indicate that CUR-DA adopts a triple-stranded helical structure in water- or methanol-rich solutions of dimethyl sulfoxide (DMSO). This triple-stranded helical structure exhibits high thermal stability and resistance to base, attributes that are similar to those of the triple-stranded helical structure of native β-1,3-glucans such as schizophyllan. Moreover, we found that the stability of the triple-stranded helical structure can be easily modulated by solvent composition and metal-ion (Zn2+) binding. As β-1,3-ghican polysaccharides are known to serve as "polymeric" hosts, including certain DNA molecules, carbon nanotubes, and conjugated polymers, and complexation occurs only with the single-stranded structure, this information is very useful for the creation of these attractive polymeric composites, the controlled release of DNA, and so on.

本文言語英語
ページ(範囲)1290-1298
ページ数9
ジャーナルChemistry - An Asian Journal
2
10
DOI
出版ステータス出版済み - 10 16 2007

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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