抄録
Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separately. Each of the other purine-ending sense codon sets (NNR) specifies a single amino acid in the universal genetic code. In bacteria and archaea, the cytidine derivatives, 2-lysylcytidine (L or lysidine) and 2-agmatinylcytidine (agm 2 C or agmatidine), respectively, are found at the first letter of the anticodon of tRNA Ile responsible for AUA codons. These modifications prevent base pairing with G of the third letter of AUG codon, and enable tRNA Ile to decipher AUA codon specifically. In addition, these modifications confer a charging ability of tRNA Ile with Ile. Despite their similar chemical structures, L and agm 2 C are synthesized by distinctive mechanisms and catalyzed by different classes of enzymes, implying that the analogous decoding systems for AUA codons were established by convergent evolution after the phylogenic split between bacteria and archaea-eukaryotes lineages following divergence from the last universal common ancestor (LUCA).
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1586-1596 |
| ページ数 | 11 |
| ジャーナル | RNA biology |
| 巻 | 11 |
| 発行部数 | 12 |
| DOI | |
| 出版物ステータス | 出版済み - 12 1 2014 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology
これを引用
Convergent evolution of AUA decoding in bacteria and archaea. / Suzuki, Tsutomu; Numata, Tomoyuki.
：: RNA biology, 巻 11, 番号 12, 01.12.2014, p. 1586-1596.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Convergent evolution of AUA decoding in bacteria and archaea
AU - Suzuki, Tsutomu
AU - Numata, Tomoyuki
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separately. Each of the other purine-ending sense codon sets (NNR) specifies a single amino acid in the universal genetic code. In bacteria and archaea, the cytidine derivatives, 2-lysylcytidine (L or lysidine) and 2-agmatinylcytidine (agm 2 C or agmatidine), respectively, are found at the first letter of the anticodon of tRNA Ile responsible for AUA codons. These modifications prevent base pairing with G of the third letter of AUG codon, and enable tRNA Ile to decipher AUA codon specifically. In addition, these modifications confer a charging ability of tRNA Ile with Ile. Despite their similar chemical structures, L and agm 2 C are synthesized by distinctive mechanisms and catalyzed by different classes of enzymes, implying that the analogous decoding systems for AUA codons were established by convergent evolution after the phylogenic split between bacteria and archaea-eukaryotes lineages following divergence from the last universal common ancestor (LUCA).
AB - Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separately. Each of the other purine-ending sense codon sets (NNR) specifies a single amino acid in the universal genetic code. In bacteria and archaea, the cytidine derivatives, 2-lysylcytidine (L or lysidine) and 2-agmatinylcytidine (agm 2 C or agmatidine), respectively, are found at the first letter of the anticodon of tRNA Ile responsible for AUA codons. These modifications prevent base pairing with G of the third letter of AUG codon, and enable tRNA Ile to decipher AUA codon specifically. In addition, these modifications confer a charging ability of tRNA Ile with Ile. Despite their similar chemical structures, L and agm 2 C are synthesized by distinctive mechanisms and catalyzed by different classes of enzymes, implying that the analogous decoding systems for AUA codons were established by convergent evolution after the phylogenic split between bacteria and archaea-eukaryotes lineages following divergence from the last universal common ancestor (LUCA).
UR - http://www.scopus.com/inward/record.url?scp=84924957061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924957061&partnerID=8YFLogxK
U2 - 10.4161/15476286.2014.992281
DO - 10.4161/15476286.2014.992281
M3 - Review article
VL - 11
SP - 1586
EP - 1596
JO - RNA Biology
JF - RNA Biology
SN - 1547-6286
IS - 12
ER -