Convergent synthesis of the FGHI ring system of yessotoxin: Stereoselective construction of the G ring

Koji Watanabe, Miho Suzuki, Michio Murata, Tohru Oishi

研究成果: Contribution to journalArticle査読

33 被引用数 (Scopus)

抄録

A convergent synthetic route to the FGHI ring system of yessotoxin, a marine ladder polyether, has been developed. The synthesis features convergent coupling of the diol and the aldehyde to form α-cyano ethers via acetal formation followed by ring closing metathesis and reductive etherification to construct the oxocane ring G and tetrahydropyran ring H, respectively. The β-methyl group on the G ring was stereoselectively introduced by alkylation of the corresponding ketone.

本文言語英語
ページ(範囲)3991-3995
ページ数5
ジャーナルTetrahedron Letters
46
23
DOI
出版ステータス出版済み - 6 6 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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