Convergent Synthesis of the WXYZA′B′C′D′E′F′ Ring Segment of Maitotoxin

Keitaro Umeno, Hisaaki Onoue, Keiichi Konoki, Kohei Torikai, Yoko Yasuno, Masayuki Satake, Tohru Oishi

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Synthesis of the WXYZA′B′C′D′E′F′ ring segment of maitotoxin, a ladder-shaped polyether produced by the dinoflagellate Gambierdiscus toxicus, was achieved based on a convergent strategy via α-cyano ethers developed in our laboratory. The WXYZ ring aldehyde and the C′D′E′F′ diol were combined through the construction of the B′ ring via ringclosing metathesis and the A′ ring via O,S-acetal formation followed by radical reduction. Introduction of a terminal olefin in the side chain culminated in the convergent synthesis of the WXYZA′B′C′D′E′F′ ring segment in 16 steps.

本文言語英語
ページ(範囲)325-330
ページ数6
ジャーナルBulletin of the Chemical Society of Japan
95
2
DOI
出版ステータス出版済み - 2022

!!!All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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