Cooperative interaction within RNA virus mutant spectra

Yuta Shirogane, Shumpei Watanabe, Yusuke Yanagi

研究成果: 著書/レポートタイプへの貢献

7 引用 (Scopus)

抄録

RNA viruses usually consist of mutant spectra because of high error rates of viral RNA polymerases. Growth competition occurs among different viral variants, and the fittest clones predominate under given conditions. Individual variants, however, may not be entirely independent of each other, and internal interactions within mutant spectra can occur. Examples of cooperative and interfering interactions that exert enhancing and suppressing effects on replication of the wild-type virus, respectively, have been described, but their underlying mechanisms have not been well defined. It was recently found that the cooperation between wild-type and variant measles virus genomes produces a new phenotype through the heterooligomer formation of a viral protein. This observation provides a molecular mechanism underlying cooperative interactions within mutant spectra. Careful attention to individual sequences, in addition to consensus sequences, may disclose further examples of internal interactions within mutant spectra.

元の言語英語
ホスト出版物のタイトルCurrent Topics in Microbiology and Immunology
出版者Springer Verlag
ページ219-229
ページ数11
DOI
出版物ステータス出版済み - 3 1 2016

出版物シリーズ

名前Current Topics in Microbiology and Immunology
392
ISSN(印刷物)0070-217X
ISSN(電子版)2196-9965

Fingerprint

Measles virus
RNA Viruses
Consensus Sequence
Viral RNA
Viral Proteins
DNA-Directed RNA Polymerases
Virus Replication
Clone Cells
Genome
Phenotype
Growth

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

これを引用

Shirogane, Y., Watanabe, S., & Yanagi, Y. (2016). Cooperative interaction within RNA virus mutant spectra. : Current Topics in Microbiology and Immunology (pp. 219-229). (Current Topics in Microbiology and Immunology; 巻数 392). Springer Verlag. https://doi.org/10.1007/82_2015_461

Cooperative interaction within RNA virus mutant spectra. / Shirogane, Yuta; Watanabe, Shumpei; Yanagi, Yusuke.

Current Topics in Microbiology and Immunology. Springer Verlag, 2016. p. 219-229 (Current Topics in Microbiology and Immunology; 巻 392).

研究成果: 著書/レポートタイプへの貢献

Shirogane, Y, Watanabe, S & Yanagi, Y 2016, Cooperative interaction within RNA virus mutant spectra. : Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, 巻. 392, Springer Verlag, pp. 219-229. https://doi.org/10.1007/82_2015_461
Shirogane Y, Watanabe S, Yanagi Y. Cooperative interaction within RNA virus mutant spectra. : Current Topics in Microbiology and Immunology. Springer Verlag. 2016. p. 219-229. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82_2015_461
Shirogane, Yuta ; Watanabe, Shumpei ; Yanagi, Yusuke. / Cooperative interaction within RNA virus mutant spectra. Current Topics in Microbiology and Immunology. Springer Verlag, 2016. pp. 219-229 (Current Topics in Microbiology and Immunology).
@inbook{e4d7e9373dd64d5d8aca749a8c4e05d3,
title = "Cooperative interaction within RNA virus mutant spectra",
abstract = "RNA viruses usually consist of mutant spectra because of high error rates of viral RNA polymerases. Growth competition occurs among different viral variants, and the fittest clones predominate under given conditions. Individual variants, however, may not be entirely independent of each other, and internal interactions within mutant spectra can occur. Examples of cooperative and interfering interactions that exert enhancing and suppressing effects on replication of the wild-type virus, respectively, have been described, but their underlying mechanisms have not been well defined. It was recently found that the cooperation between wild-type and variant measles virus genomes produces a new phenotype through the heterooligomer formation of a viral protein. This observation provides a molecular mechanism underlying cooperative interactions within mutant spectra. Careful attention to individual sequences, in addition to consensus sequences, may disclose further examples of internal interactions within mutant spectra.",
author = "Yuta Shirogane and Shumpei Watanabe and Yusuke Yanagi",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/82_2015_461",
language = "English",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Verlag",
pages = "219--229",
booktitle = "Current Topics in Microbiology and Immunology",
address = "Germany",

}

TY - CHAP

T1 - Cooperative interaction within RNA virus mutant spectra

AU - Shirogane, Yuta

AU - Watanabe, Shumpei

AU - Yanagi, Yusuke

PY - 2016/3/1

Y1 - 2016/3/1

N2 - RNA viruses usually consist of mutant spectra because of high error rates of viral RNA polymerases. Growth competition occurs among different viral variants, and the fittest clones predominate under given conditions. Individual variants, however, may not be entirely independent of each other, and internal interactions within mutant spectra can occur. Examples of cooperative and interfering interactions that exert enhancing and suppressing effects on replication of the wild-type virus, respectively, have been described, but their underlying mechanisms have not been well defined. It was recently found that the cooperation between wild-type and variant measles virus genomes produces a new phenotype through the heterooligomer formation of a viral protein. This observation provides a molecular mechanism underlying cooperative interactions within mutant spectra. Careful attention to individual sequences, in addition to consensus sequences, may disclose further examples of internal interactions within mutant spectra.

AB - RNA viruses usually consist of mutant spectra because of high error rates of viral RNA polymerases. Growth competition occurs among different viral variants, and the fittest clones predominate under given conditions. Individual variants, however, may not be entirely independent of each other, and internal interactions within mutant spectra can occur. Examples of cooperative and interfering interactions that exert enhancing and suppressing effects on replication of the wild-type virus, respectively, have been described, but their underlying mechanisms have not been well defined. It was recently found that the cooperation between wild-type and variant measles virus genomes produces a new phenotype through the heterooligomer formation of a viral protein. This observation provides a molecular mechanism underlying cooperative interactions within mutant spectra. Careful attention to individual sequences, in addition to consensus sequences, may disclose further examples of internal interactions within mutant spectra.

UR - http://www.scopus.com/inward/record.url?scp=84961626366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961626366&partnerID=8YFLogxK

U2 - 10.1007/82_2015_461

DO - 10.1007/82_2015_461

M3 - Chapter

C2 - 26162566

AN - SCOPUS:84961626366

T3 - Current Topics in Microbiology and Immunology

SP - 219

EP - 229

BT - Current Topics in Microbiology and Immunology

PB - Springer Verlag

ER -