TY - JOUR
T1 - Coordination of multiple cellular processes by NR5A1/Nr5a1
AU - Morohashi, Ken Ichirou
AU - Inoue, Miki
AU - Baba, Takashi
N1 - Funding Information:
The authors are supported by grants JSPS KAKENHI Grant Number JP20H03436 (Ken-ichirou Morohashi), JP17H06427 (Ken-ichirou Morohashi, Takashi Baba), and JP20K08863 (Ta-kashi Baba); by AMED under Grant Number JP20gk0210019 (Ken-ichirou Morohashi).
Publisher Copyright:
© 2020 Korean Endocrine Society. All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newly-established technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.
AB - The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newly-established technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.
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U2 - 10.3803/ENM.2020.402
DO - 10.3803/ENM.2020.402
M3 - Review article
C2 - 33397036
AN - SCOPUS:85099085783
VL - 35
SP - 756
EP - 764
JO - Endocrinology and Metabolism
JF - Endocrinology and Metabolism
SN - 2093-596X
IS - 4
ER -