@article{170bdb45fd2b49b3958987da50b98c70,
title = "Copper-Catalyzed Tertiary Alkylative Cyanation for the Synthesis of Cyanated Peptide Building Blocks",
abstract = "In this paper, we report efficient cyanation of various peptides containing the α-bromocarbonyl moiety using a Cu-catalyzed radical-based methodology employing zinc cyanide as the cyanide source. Mechanistic studies revealed that in situ formed CuCN was a key intermediate during the catalytic cycle. Our method could be useful for the synthesis of modified peptides containing quaternary carbons.",
author = "Naoki Miwa and Chihiro Tanaka and Syo Ishida and Goki Hirata and Jizhou Song and Takeru Torigoe and Yoichiro Kuninobu and Takashi Nishikata",
note = "Funding Information: We warmly thank Yamaguchi University (T.N.), the Naito Foundation, JSPS KAKENHI for Grant Numbers JP18H04654 and 18H04656 in Hybrid Catalysis for Enabling Molecular Synthesis on Demand (T.N. and Y.K.), and JSPS KAKENHI for Grant Number 18K19182 in Challenging Research (Exploratory) (T.N.).",
year = "2020",
month = jan,
day = "29",
doi = "10.1021/jacs.9b11349",
language = "English",
volume = "142",
pages = "1692--1697",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "4",
}