Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis

Takuro Kuriyama, Koji Kato, Keiji Sakamoto, Masayasu Hayashi, Shuichiro Takashima, Yasuo Mori, Katsuto Takenaka, Hiromi Iwasaki, Takanori Teshima, Naoki Harada, Koji Nagafuji, Toshihiro Miyamoto, Koichi Akashi

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Inherited hemophagocytic lymphohistiocytosis (HLH) is a genetic anomaly disorder in which abnormally activated cytotoxic T lymphocytes cannot induce the apoptosis of target cells and antigen-presenting cells, leading to hemophagocytosis, pancytopenia, and a variety of symptoms such as a high fever. The present patient with adult-onset HLH developed refractory disease despite receiving immunosuppressive treatments. He underwent a reduced-intensity conditioning (RIC) regimen that comprised antithymocyte globulin (ATG) followed by cord blood transplantation (RIC-CBT). He achieved and maintained a complete donor type. The incorporation of ATG into RIC-CBT may prevent graft failure and control hemophagocytosis, however, further efforts are necessary to reduce infectious complications.

本文言語英語
ページ(範囲)667-671
ページ数5
ジャーナルInternal Medicine
55
6
DOI
出版ステータス出版済み - 3 15 2016

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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