Cord Blood Transplantation for Multiple Myeloma: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation

Koji Kawamura, Hiroyuki Takamatsu, Takashi Ikeda, Tsunehiko Komatsu, Nobuyuki Aotsuka, Itsuto Amano, Go Yamamoto, Kentaro Watanabe, Yuju Ohno, Kosei Matsue, Yasuji Kouzai, Nobuhiro Tsukada, Ken Ishiyama, Naoyuki Anzai, Koji Kato, Ritsuro Suzuki, Kazutaka Sunami, Yoshinobu Kanda

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

Cord blood has been investigated as an alternative source for hematopoietic stem cell transplantation, but information about its use for multiple myeloma is limited. The purpose of this study was to evaluate the feasibility of cord blood transplantation (CBT) for patients with multiple myeloma. Eighty-six patients with multiple myeloma who underwent a first CBT between 2001 and 2011 were included in this retrospective study. Sixty-two of them had received other types of stem cell transplantation before CBT. The cumulative incidences of neutrophil engraftment at day 50, grade II to IV acute graft-versus-host disease (GVHD), and chronic GVHD were 81.4%, 39.0%, and 19.5%, respectively. The incidence of nonrelapse mortality at 2 years was 39.0%, but it was only 6.2% in patients who underwent planned tandem autologous/reduced-intensity conditioning CBT (auto/RIC-CBT). Progression-free survival (PFS) and overall survival (OS) at 6 years were 13.0% and 15.2%, respectively. Less than a partial response before CBT and lack of prior transplantation were independent significant adverse factors for PFS, whereas the presence of prior transplantation and planned tandem transplantation were associated with better OS. OS at 6 years in patients who underwent auto/RIC-CBT was 45.9%. In addition, the development of chronic GVHD was associated with superior PFS. In conclusion, we demonstrated that cord blood is feasible as an alternative graft source for myeloma patients. Although CBT provided long-term survival for a fraction of patients, optimal use of this graft requires further clinical studies.

本文言語英語
ページ(範囲)1291-1298
ページ数8
ジャーナルBiology of Blood and Marrow Transplantation
21
7
DOI
出版ステータス出版済み - 7月 1 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 血液学
  • 移植

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