Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors

kazufumi kikuchi, Hiwatashi Akio, Osamu Togao, Koji Yamashita, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Traditional MRI methods for estimation of blood flow in brain tumors require high-flow injection of contrast agents through large-bore intravenous access, which limits their pediatric utility. In contrast, arterial spin-labeling (ASL) can be used without contrast media. This study aimed to evaluate the relationship between tumor blood flow (TBF) measured by ASL and histopathological vascular density in pediatric brain tumors. Nineteen consecutive children were evaluated (10 boys, 9 girls; median age: 6 years; 8 high-grade and 11 low-grade tumors). ASL was performed with a pseudocontinuous labeling time of 1650 ms and post-labeling delay of 1525 ms. The maximal absolute (aTBF) and relative (rTBF) tumor blood flows were measured. To evaluate the relative vascular area (%Vessel), the total stained vascular area was divided by the whole tissue area. Spearman’s rank-order correlation, the Mann–Whitney U test, and receiver operating characteristic analysis were used for statistical analysis. The absolute and relative TBF rates were 4.9–92.9 mL/100 g/min and 0.17–3.59 mL/100 g/min, respectively. The %Vessel was 0.6–30.2%. The %Vessel showed a significant positive correlation with TBF (aTBF: r = 0.87, P < 0.0001; rTBF: r = 0.89, P < 0.0001). The TBF rate of high-grade tumors was significantly higher than that of low-grade tumors (aTBF: P = 0.0050, rTBF: P = 0.0036). The rTBF had the best diagnostic performance (area under the curve: 0.89). ASL perfusion imaging without contrast material can be used for accurate evaluation of histopathological vascular density and may be helpful for tumor grading in children.

元の言語英語
ページ(範囲)561-569
ページ数9
ジャーナルJournal of Neuro-Oncology
135
発行部数3
DOI
出版物ステータス出版済み - 12 1 2017

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Blood Vessels
Perfusion
Pediatrics
Neoplasms
Contrast Media
Brain Neoplasms
Perfusion Imaging
Neoplasm Grading
ROC Curve
Area Under Curve
Injections

All Science Journal Classification (ASJC) codes

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

これを引用

Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors. / kikuchi, kazufumi; Akio, Hiwatashi; Togao, Osamu; Yamashita, Koji; Yoshimoto, Koji; Mizoguchi, Masahiro; Suzuki, Satoshi; Iwaki, Toru; Suzuki, Yuriko; Honda, Hiroshi.

:: Journal of Neuro-Oncology, 巻 135, 番号 3, 01.12.2017, p. 561-569.

研究成果: ジャーナルへの寄稿記事

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title = "Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors",
abstract = "Traditional MRI methods for estimation of blood flow in brain tumors require high-flow injection of contrast agents through large-bore intravenous access, which limits their pediatric utility. In contrast, arterial spin-labeling (ASL) can be used without contrast media. This study aimed to evaluate the relationship between tumor blood flow (TBF) measured by ASL and histopathological vascular density in pediatric brain tumors. Nineteen consecutive children were evaluated (10 boys, 9 girls; median age: 6 years; 8 high-grade and 11 low-grade tumors). ASL was performed with a pseudocontinuous labeling time of 1650 ms and post-labeling delay of 1525 ms. The maximal absolute (aTBF) and relative (rTBF) tumor blood flows were measured. To evaluate the relative vascular area ({\%}Vessel), the total stained vascular area was divided by the whole tissue area. Spearman’s rank-order correlation, the Mann–Whitney U test, and receiver operating characteristic analysis were used for statistical analysis. The absolute and relative TBF rates were 4.9–92.9 mL/100 g/min and 0.17–3.59 mL/100 g/min, respectively. The {\%}Vessel was 0.6–30.2{\%}. The {\%}Vessel showed a significant positive correlation with TBF (aTBF: r = 0.87, P < 0.0001; rTBF: r = 0.89, P < 0.0001). The TBF rate of high-grade tumors was significantly higher than that of low-grade tumors (aTBF: P = 0.0050, rTBF: P = 0.0036). The rTBF had the best diagnostic performance (area under the curve: 0.89). ASL perfusion imaging without contrast material can be used for accurate evaluation of histopathological vascular density and may be helpful for tumor grading in children.",
author = "kazufumi kikuchi and Hiwatashi Akio and Osamu Togao and Koji Yamashita and Koji Yoshimoto and Masahiro Mizoguchi and Satoshi Suzuki and Toru Iwaki and Yuriko Suzuki and Hiroshi Honda",
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T1 - Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors

AU - kikuchi, kazufumi

AU - Akio, Hiwatashi

AU - Togao, Osamu

AU - Yamashita, Koji

AU - Yoshimoto, Koji

AU - Mizoguchi, Masahiro

AU - Suzuki, Satoshi

AU - Iwaki, Toru

AU - Suzuki, Yuriko

AU - Honda, Hiroshi

PY - 2017/12/1

Y1 - 2017/12/1

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