Correlation of central blood pressure to hypertensive target organ damages during antihypertensive treatment: The J-TOP study

Motohiro Shimizu, Satoshi Hoshide, Joji Ishikawa, Yuichiro Yano, Kazuo Eguchi, Kazuomi Kario

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

BACKGROUND Some previous studies have shown that central blood pressure (BP) is more closely related to cardiovascular risks than brachial BP. This study compared the correlations between asymptomatic organ damages and each of central BP, brachial clinic BP, and home BP during antihypertensive treatment. METHODS In the Japan Morning Surge-Target Organ Protection (J-TOP) study, which compared bedtime or awakening dosing of candesartan (+diuretics as needed) among subjects with home systolic BP (SBP) higher than 135mm Hg, we evaluated 180 hypertensive patients who successfully underwent pulse wave analysis by HEM-9000AI and measured their urinary albumin/creatinine ratio (UACR) and left ventricular mass index (LVMI) (n = 144) at baseline and after 6 months of treatment. RESULTS During antihypertensive treatment, significant reductions were found in central SBP, UACR, and LVMI (all P < 0.001). Multiple regression analyses showed that the decrease in central SBP was associated with those of log-transformed UACR (β = 0.24, P < 0.01) and LVMI (β = 0.23, P = 0.04), independently of the decrease in both clinic and home SBP. The goodness-of-fit of the association between the reduction in SBP and the UACR (P < 0.01) or LVMI (P = 0.04) was improved by adding central SBP to the SBP measurement. CONCLUSION These findings suggest that the change in central BP could be an important therapeutic target during antihypertensive treatment, in addition to peripheral clinic and home BP.

元の言語英語
ページ(範囲)980-986
ページ数7
ジャーナルAmerican Journal of Hypertension
28
発行部数8
DOI
出版物ステータス出版済み - 5 11 2015

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Antihypertensive Agents
Japan
Blood Pressure
Albumins
Creatinine
Therapeutics
Arm
Pulse Wave Analysis
Diuretics
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Correlation of central blood pressure to hypertensive target organ damages during antihypertensive treatment : The J-TOP study. / Shimizu, Motohiro; Hoshide, Satoshi; Ishikawa, Joji; Yano, Yuichiro; Eguchi, Kazuo; Kario, Kazuomi.

:: American Journal of Hypertension, 巻 28, 番号 8, 11.05.2015, p. 980-986.

研究成果: ジャーナルへの寄稿記事

Shimizu, Motohiro ; Hoshide, Satoshi ; Ishikawa, Joji ; Yano, Yuichiro ; Eguchi, Kazuo ; Kario, Kazuomi. / Correlation of central blood pressure to hypertensive target organ damages during antihypertensive treatment : The J-TOP study. :: American Journal of Hypertension. 2015 ; 巻 28, 番号 8. pp. 980-986.
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