Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas

Tomohiro Yamada, Moritoshi Uchida, Kang Kwang-Lee, Naoya Kitamura, Tomohide Yoshimura

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)

抄録

Objective. The objective of this study was to analyze the relationship between the uptake of 18F-2-fluoro-2-deoxy-D-glucose (FDG) by positron emission tomography-computerized tomography (PET-CT) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (OSCC). Study Design. Thirty-six patients with OSCC (tongue [n 23], buc al mucosa [n 7], and floor of the mouth [n 6]) were assessed and underwent incisional biopsy and subsequently received FDG-PET-CT. Expressions of hypoxia-inducible factor 1α (HIF-1α), glucose transporter protein 1 (GLUT-1), hexokinase-II (HK-II), and glucose-6-phosphatase (G6Pase) were immunohistochemically quantified, and FDG uptake was evaluated by the maximum standardized uptake values (SUV max) at the primary tumor site. Results. FDG uptake was found to be significantly correlated with the T classification of OSCC but not with other clinicopathologic characteristics, such as the N classification, clinical type, and histologic grade of malignancy. In the earlystage (T1 and T2) tumor, FDG uptake was significantly associated with the expression levels of GLUT-1, HK II, and HIF-1, and the expression levels of GLUT-1 and HK-II significantly correlated with HIF-1 expression levels. However, there were no correlations between the expression levels of these molecules and SUVmax in the late-stage (T3 and T4) tumor. Conclusions. FDG uptake was significantly associated with the expression levels of glucose metabolism-related molecules, such as GLUT-1, HK II, and HIF-1α, especially in early-stage tumors.

本文言語英語
ページ(範囲)464-471
ページ数8
ジャーナルOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
113
4
DOI
出版ステータス出版済み - 4 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 口腔外科
  • 病理学および法医学
  • 歯科学(その他)
  • 放射線学、核医学およびイメージング

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