Correlations of amide proton transferweighted MRI of cerebral infarction with clinico-radiological findings

Daichi Momosaka, Osamu Togao, Kazufumi Kikuchi, Yoshitomo Kikuchi, Yoshinobu Wakisaka, Akio Hiwatashi

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Objective To clarify the relationship between amide proton transfer-weighted (APTW) signal, which reflects intracellular pH, and clinico-radiological findings in patients with hyperacute to subacute cerebral infarction. Materials and methods Twenty-nine patients (median age, 70 years [IQR, 54 to 74]; 15 men) were retrospectively examined. The 10th, 25th, 50th, 75th, and 90th percentiles of APTW signal (APT10, APT25, APT50, APT75 and APT90, respectively) were measured within the infarction region-of-interest (ROI), and compared between poor prognosis and good prognosis groups (modified Rankin Scale [mRS] score ≥2 and mRS score <2, respectively). Correlations between APTW signal and time after onset, lesion size, National Institutes of Health Stroke Scale (NIHSS) score, mRS score, and mean apparent diffusion coefficient (ADC) were evaluated. Results The poor prognosis group had lower APT50, APT75 and APT90 than the good prognosis group (-0.66 [-1.19 to -0.27] vs. -0.09 [-0.62 to -0.21]; -0.27 [-0.63 to -0.01] vs. 0.31 [-0.15 to 1.06]; 0.06 [-0.21 to 0.34] vs. 0.93 [0.36 to 1.50] %; p <0.05, respectively). APT50 was positively correlated with time after onset (r = 0.37, p = 0.0471) and negatively with lesion size (r = -0.39, p = 0.0388). APT75 and APT90 were negatively correlated with NIHSS (r = -0.41 and -0.43; p <0.05, respectively). APT50, APT75 and APT90 were negatively correlated with mRS (r = -0.37, -0.52 and -0.57; p <0.05, respectively). APT10 and APT25 were positively correlated with mean ADC (r = 0.37 and 0.38; p <0.05, respectively). Conclusion We demonstrated correlations between APTW signals of infarctions and clinico-radiological findings in patients with hyperacute to subacute infarctions. The poor prognosis group had a lower APTW signal than the good prognosis group. APTW signal was reduced in large infarctions, infarctions with low ADC, and in patients with high NIHSS and mRS scores.

本文言語英語
論文番号e0237358
ジャーナルPloS one
15
8 August
DOI
出版ステータス出版済み - 8月 2020

!!!All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 一般

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