Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction

T. Yamamoto, K. Hirano, H. Tsutsui, Y. Sugioka, K. Sueishi

研究成果: ジャーナルへの寄稿学術誌査読

104 被引用数 (Scopus)

抄録

Bacterial endotoxic reactions can cause osteonecrosis in humans by disseminated intravascular coagulation. The authors first used a combination of the Shwartzman reaction and corticoid injections in rabbits to develop a new animal model of osteonecrosis. This model showed a significantly higher incidence and wider area of osteonecrosis in the femur and humerus than that found in rabbits with either Shwartzman reaction or steroid injection alone. Osteonecrosis was observed in several foci that were distributed from the diaphysis to the epiphysis in both bones. Histologically, the bone marrow cells underwent necrosis, whereas the bone trabeculae demonstrated either empty lacunae or pycnotic nuclei of osteocytes. Exogenous steroids appeared to potentiate the Shwartzman reaction and the magnitude of osteonecrosis, perhaps by increasing endothelial damage and hypercoagulability of those intraosseous and extraosseous vessels that subsequently thrombosed. This model may not only be useful in clarifying the etiology and early pathogenesis of human osteonecrosis after corticoid therapy, but also in designing pharmaceuticals for prevention and early treatment.

本文言語英語
ページ(範囲)235-243
ページ数9
ジャーナルClinical orthopaedics and related research
316
DOI
出版ステータス出版済み - 1月 1 1995

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 整形外科およびスポーツ医学

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