Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice

Masaki Fujita, Hiroshi Ouchi, Satoshi Ikegame, Eiji Harada, Takemasa Matsumoto, Junji Uchino, Yoichi Nakanishi, Kentaro Watanabe

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)


COPD is a major cause of chronic morbidity and mortality throughout the world. Although tumor necrosis factor-α (TNF-α) has a critical role in the development of COPD, the role of different TNF receptors (TNFRs) in pulmonary emphysema has not been resolved. We aimed to clarify the role of TNFRs in the development of pulmonary emphysema. TNF-α transgenic mice, a murine model of COPD in which the mice spontaneously develop emphysema with a large increase in lung volume and pulmonary hypertension, were crossed with either TNFR1-deficient mice or TNFR2-deficient mice. After 6months, the gross appearance of the lung, lung histology, and pulmonary and cardiac physiology were determined. In addition, the relationship between apoptosis and emphysema was investigated. Pulmonary emphysema-like changes disappeared with deletion of TNFR1. However, slight improvements were attained with deletion of TNFR2. Apoptotic cells in the interstitium of the lung were observed in TNF-α transgenic mice. The apoptotic signals through TNFR1 appear critical for the pathogenesis of pulmonary emphysema. In contrast, the inflammatory process has a less important role for the development of emphysema.

ジャーナルInternational Journal of COPD
出版ステータス出版済み - 7月 28 2016

All Science Journal Classification (ASJC) codes

  • 呼吸器内科
  • 健康政策
  • 公衆衛生学、環境および労働衛生


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