Crocin and crocetin derivatives inhibit skin tumour promotion in mice

T. Konoshima, M. Takasaki, H. Tokuda, S. Morimoto, H. Tanaka, E. Kawata, L. J. Xuan, H. Saito, M. Sugiura, J. Molnar, Y. Shoyama

研究成果: Contribution to journalArticle査読

62 被引用数 (Scopus)


The addition of 100 μg/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV-EA activation and preserved the high viability of Raji cells. The attenuating effect of ECS was dose- dependent. The oral administration of ECS demonstrated an inhibitory effect on two-stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di-glucose ester were less potent than crocin in inhibiting the EBV- EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma. The effect of crocin was not mimicked by gentiobiose or glucose alone.

ジャーナルPhytotherapy Research
出版ステータス出版済み - 9 1998

All Science Journal Classification (ASJC) codes

  • 薬理学


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