Crocin promotes non-rapid eye movement sleep in mice

Mika Masaki, Kosuke Aritake, Hiroyuki Tanaka, Yukihiro Shoyama, Zhi Li Huang, Yoshihiro Urade

研究成果: Contribution to journalArticle査読

39 被引用数 (Scopus)

抄録

Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L. In this study, we examined the sleep-promoting activity of crocin and crocetin by monitoring the locomotor activity and electroencephalogram after administration of these components to mice. Crocin (30 and 100 mg/kg) increased the total time of non-rapid eye movement (non-REM) sleep by 60 and 170%, respectively, during a 4-h period from 20:00 to 24:00 after its intraperitoneal administration at a lights-off time of 20:00. Crocetin (100 mg/kg) also increased the total time of non-REM sleep by 50% after the administration. These compounds did not change the amount of REM sleep or show any adverse effects, such as rebound insomnia, after the induction of sleep.

本文言語英語
ページ(範囲)304-308
ページ数5
ジャーナルMolecular Nutrition and Food Research
56
2
DOI
出版ステータス出版済み - 2 2012

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 食品科学

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