Cromakalim dilates rat cerebral arteries in vitro

Tetsuhiko Nagao, Seizo Sadoshima, Masahiro Kamouchi, Masatoshi Fujishima

研究成果: ジャーナルへの寄稿学術誌査読

32 被引用数 (Scopus)

抄録

Using an in vitro perfusion method, we examined the effects of cromakalim, a potassium channel opener, on the superior cerebellar arteries of 24 rats. Cromakalim had no effect on contractions induced by 129 mM K+ until a concentration of 10-5 M was reached. Contractions evoked by 10-5 M serotonin were attenuated by cromakalim in a con centrat ion-dependent manner (p <0.05). The diameter of untreated superior cerebellar arteries remained almost constant with increasing perfusion pressure. However, in the presence of cromakalim, vessel diameter increased with increasing perfusion pressure. At concentrations of 3×10-6 M, cromakalim also inhibited basal myogenic tone and dilated unstimulated arteries (p <0.01). These results suggest that cromakalim is a cerebrovascular dilator acting on both receptor-mediated and myogenic contractions.

本文言語英語
ページ(範囲)221-224
ページ数4
ジャーナルStroke
22
2
DOI
出版ステータス出版済み - 2月 1991

!!!All Science Journal Classification (ASJC) codes

  • 臨床神経学
  • 循環器および心血管医学
  • 高度および特殊看護

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