Cromakalim dilates rat cerebral arteries in vitro

Tetsuhiko Nagao, Seizo Sadoshima, Masahiro Kamouchi, Masatoshi Fujishima

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

抄録

Using an in vitro perfusion method, we examined the effects of cromakalim, a potassium channel opener, on the superior cerebellar arteries of 24 rats. Cromakalim had no effect on contractions induced by 129 mM K+ until a concentration of 10-5 M was reached. Contractions evoked by 10-5 M serotonin were attenuated by cromakalim in a con centrat ion-dependent manner (p <0.05). The diameter of untreated superior cerebellar arteries remained almost constant with increasing perfusion pressure. However, in the presence of cromakalim, vessel diameter increased with increasing perfusion pressure. At concentrations of 3×10-6 M, cromakalim also inhibited basal myogenic tone and dilated unstimulated arteries (p <0.01). These results suggest that cromakalim is a cerebrovascular dilator acting on both receptor-mediated and myogenic contractions.

元の言語英語
ページ(範囲)221-224
ページ数4
ジャーナルStroke
22
発行部数2
DOI
出版物ステータス出版済み - 1 1 1991

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Cromakalim
Cerebral Arteries
Arteries
Perfusion
Pressure
Potassium Channels
In Vitro Techniques
Serotonin
Ions

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

これを引用

Cromakalim dilates rat cerebral arteries in vitro. / Nagao, Tetsuhiko; Sadoshima, Seizo; Kamouchi, Masahiro; Fujishima, Masatoshi.

:: Stroke, 巻 22, 番号 2, 01.01.1991, p. 221-224.

研究成果: ジャーナルへの寄稿記事

Nagao, T, Sadoshima, S, Kamouchi, M & Fujishima, M 1991, 'Cromakalim dilates rat cerebral arteries in vitro', Stroke, 巻. 22, 番号 2, pp. 221-224. https://doi.org/10.1161/01.STR.22.2.221
Nagao, Tetsuhiko ; Sadoshima, Seizo ; Kamouchi, Masahiro ; Fujishima, Masatoshi. / Cromakalim dilates rat cerebral arteries in vitro. :: Stroke. 1991 ; 巻 22, 番号 2. pp. 221-224.
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