Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution

Akio Ojida, Masa Aki Inoue, Yasuko Mito-oka, Itaru Hamachi

研究成果: ジャーナルへの寄稿学術誌査読

106 被引用数 (Scopus)

抄録

In the research field of molecular recognition, selective recognition and sensing of phosphorylated protein surfaces is strongly desirable both for elucidation of protein-protein recognition at the molecular level and for regulation of signal transduction through protein surfaces. Here we describe a new strategy for molecular recognition of a multi-phosphorylated peptide using intrapeptide cross-linking on the basis of coordination chemistry. The present artificial receptor can selectively bind to doubly phosphorylated peptide through multiple-point interactions and fluorescently sense the binding event with an association constant of more than 106 M-1 in neutral aqueous solution.

本文言語英語
ページ(範囲)10184-10185
ページ数2
ジャーナルJournal of the American Chemical Society
125
34
DOI
出版ステータス出版済み - 8月 27 2003

!!!All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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