CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node

Arata Takeuchi, Yasushi Itoh, Akiko Takumi, Chitose Ishihara, Noriko Arase, Tadashi Yokosuka, Haruhiko Koseki, Sho Yamasaki, Yoshimi Takai, Jun Miyoshi, Kazumasa Ogasawara, Takashi Saito

    研究成果: ジャーナルへの寄稿学術誌査読

    41 被引用数 (Scopus)

    抄録

    In vivo immune response is triggered in the lymph node, where lymphocytes for entry into, retention at, and migration to effector sites are dynamically regulated. The molecular mechanism underlying retention regulation is the key to elucidating in vivo regulation of immune response. In this study, we describe the function of the adhesion molecule class I-restricted T cell-associated molecule (CRTAM) in regulating CD8+ T cell retention within the lymph node and eventually effector function. We previously identified CRTAM as a receptor predominantly expressed on activated CD8+ T cells, and nectin-like molecule-2 (Necl2) as its ligand. In vivo function of CRTAM-Necl2 interaction was analyzed by generating CRTAM-/- mice. CRTAM -/- mice exhibited reduced protective immunity against viral infection and impaired autoimmune diabetes induction in vivo. Although Agspecific CRTAM-/- CD8+ T cells showed normal CTL functions in vitro, their number in the draining lymph node was reduced. Because CRTAM+ T cells bound efficiently to Necl2-expressing CD8+ dendritic cells (DCs) that reside in T cell area of lymph node, CRTAM may induce retention by binding to CD8+ DCs at the late stage of activation before proliferation. The CRTAM-mediated late interaction with DCs induced retention of activated CD8+ T cells in an Ag-independent fashion, and this possibly resulted in effective CTL development in the draining lymph node.

    本文言語英語
    ページ(範囲)4220-4228
    ページ数9
    ジャーナルJournal of Immunology
    183
    7
    DOI
    出版ステータス出版済み - 10月 1 2009

    !!!All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学

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