抄録
Glucuronyltransferase I (GlcAT-I) is a key enzyme in heparan/chondroitin biosynthesis (1). The X-ray crystal structure of human GlcAT-1 has been solved in the presence of both UDP and substrate analog. The structure reveals a two sub-domain structure known as the SGC domain. Donor substrate-binding site resides in the N-terminal sub-domain, while acceptor substrate-binding site is located in the C-terminal sub-domain. In addition to conserved residues responsible for the donor binding, various residues that interact with the acceptor molecule have now been identified. The GlcAT-1 provides the structural basis for understanding the structure and function of glycosyltransferases.
本文言語 | 英語 |
---|---|
ページ(範囲) | 121-129 |
ページ数 | 9 |
ジャーナル | Trends in Glycoscience and Glycotechnology |
巻 | 13 |
号 | 70 |
DOI | |
出版ステータス | 出版済み - 3月 2001 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 有機化学