Crystal structure of endocrine-disrupting chemical bisphenol A and estrogen-related receptor γ

研究成果: ジャーナルへの寄稿総説査読

抄録

The human estrogen-related receptor γ(ERRγ) is an orphan nuclear receptor. The ERRγbehaves as a constitutive activator of transcription and plays a key role in controlling mitochondrial energy production and energy metabolism. Bisphenol A (BPA) is used mainly in producing polycarbonate plastics and epoxy resins, but it is known as an endocrine disruptor and strongly binds to ERRγ. We determined the crystal structure of ERRγin complex with BPA. Our structure revealed the molecular mechanism of BPA recognition by ERRγ, in which BPA is well anchored to its ligand-binding pocket. Our structure is the first report of the complex between a nuclear receptor and endocrine disruptor BPA. This structural analysis had a profound impact on subsequent studies of endocrine disruptors.

本文言語英語
ページ(範囲)23-25
ページ数3
ジャーナルJournal of biochemistry
171
1
DOI
出版ステータス出版済み - 1月 1 2022

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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