Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase

Takamasa Teramoto, Yoichi Sakakibara, Kanako Inada, Katsuhisa Kurogi, Ming Cheh Liu, Masahito Suiko, Makoto Kimura, Yoshimitsu Kakuta

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

In mammals, sulfonation as mediated by specific cytosolic sulfotransferases (SULTs) plays an important role in the homeostasis of dopamine and other catecholamines. To gain insight into the structural basis for dopamine recognition/binding, we determined the crystal structure of a mouse dopamine-sulfating SULT, mouse SULT1D1 (mSULT1D1). Data obtained indicated that mSULT1D1 comprises of a single α/β domain with a five-stranded parallel β-sheet. In contrast to the structure of the human SULT1A3 (hSULT1A3)-dopamine complex previously reported, molecular modeling and mutational analysis revealed that a water molecule plays a critical role in the recognition of the amine group of dopamine by mSULT1D1. These results imply differences in substrate binding between dopamine-sulfating SULTs from different species.

元の言語英語
ページ(範囲)3909-3914
ページ数6
ジャーナルFEBS Letters
582
発行部数28
DOI
出版物ステータス出版済み - 11 26 2008

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Sulfotransferases
Catecholamines
Dopamine
Arylsulfotransferase
Crystal structure
Amines
Mammals
Sulfonation
Homeostasis
Molecular modeling
Water
Molecules
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

これを引用

Teramoto, T., Sakakibara, Y., Inada, K., Kurogi, K., Liu, M. C., Suiko, M., ... Kakuta, Y. (2008). Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. FEBS Letters, 582(28), 3909-3914. https://doi.org/10.1016/j.febslet.2008.10.035

Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. / Teramoto, Takamasa; Sakakibara, Yoichi; Inada, Kanako; Kurogi, Katsuhisa; Liu, Ming Cheh; Suiko, Masahito; Kimura, Makoto; Kakuta, Yoshimitsu.

:: FEBS Letters, 巻 582, 番号 28, 26.11.2008, p. 3909-3914.

研究成果: ジャーナルへの寄稿記事

Teramoto, T, Sakakibara, Y, Inada, K, Kurogi, K, Liu, MC, Suiko, M, Kimura, M & Kakuta, Y 2008, 'Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase', FEBS Letters, 巻. 582, 番号 28, pp. 3909-3914. https://doi.org/10.1016/j.febslet.2008.10.035
Teramoto T, Sakakibara Y, Inada K, Kurogi K, Liu MC, Suiko M その他. Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. FEBS Letters. 2008 11 26;582(28):3909-3914. https://doi.org/10.1016/j.febslet.2008.10.035
Teramoto, Takamasa ; Sakakibara, Yoichi ; Inada, Kanako ; Kurogi, Katsuhisa ; Liu, Ming Cheh ; Suiko, Masahito ; Kimura, Makoto ; Kakuta, Yoshimitsu. / Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. :: FEBS Letters. 2008 ; 巻 582, 番号 28. pp. 3909-3914.
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