CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

Takahisa Tateishi, Ryo Yamasaki, Masahito Tanaka, Takuya Matsushita, Hitoshi Kikuchi, Noriko Isobe, Yasumasa Ohyagi, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

58 引用 (Scopus)

抄録

We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

元の言語英語
ページ(範囲)76-81
ページ数6
ジャーナルJournal of Neuroimmunology
222
発行部数1-2
DOI
出版物ステータス出版済み - 5 1 2010

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Amyotrophic Lateral Sclerosis
Chemokines
Cerebrospinal Fluid
Cytokines
Motor Neuron Disease
Immunoassay
Disease Progression
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. / Tateishi, Takahisa; Yamasaki, Ryo; Tanaka, Masahito; Matsushita, Takuya; Kikuchi, Hitoshi; Isobe, Noriko; Ohyagi, Yasumasa; Kira, Jun-Ichi.

:: Journal of Neuroimmunology, 巻 222, 番号 1-2, 01.05.2010, p. 76-81.

研究成果: ジャーナルへの寄稿記事

Tateishi, Takahisa ; Yamasaki, Ryo ; Tanaka, Masahito ; Matsushita, Takuya ; Kikuchi, Hitoshi ; Isobe, Noriko ; Ohyagi, Yasumasa ; Kira, Jun-Ichi. / CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. :: Journal of Neuroimmunology. 2010 ; 巻 222, 番号 1-2. pp. 76-81.
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