Culture-negative brain abscess with Streptococcus intermedius infection with diagnosis established by direct nucleotide sequence analysis of the 16s ribosomal RNA gene

Naoko Saito, Ayumi Hida, Yuri Koide, Tadasuke Ooka, Yaeko Ichikawa, Jun Shimizu, Akitake Mukasa, Hirofumi Nakatomi, Shuji Hatakeyama, Tetsuya Hayashi, Shoji Tsuji

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

A 70-year-old woman developed a headache for a month followed by right upper limb weakness. CT scan and MRI showed multiple ring-enhancing lesions. An intracerebral aspiration of an abscess was performed, but culture results were negative. The nucleotide sequence analysis of the 16S rRNA gene from the specimens identified Streptococcus intermedius. Given this result, S. intermedius was cultured by enrichment culture, and its sensitivities to antibiotics were determined. The patient exhibited complete remission. Thus, 16S rRNA gene analysis was highly useful not only for pathogen identification with negative culture results but also for the appropriate selection of antibiotics.

本文言語英語
ページ(範囲)211-216
ページ数6
ジャーナルInternal Medicine
51
2
DOI
出版ステータス出版済み - 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学

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