Current state of yusho and prospects for therapeutic strategies

Chikage Mitoma, Hiroshi Uchi, Kiyomi Tsukimori, Takashi Todaka, Jumboku Kajiwara, Takayuki Shimose, Manabu Akahane, Tomoaki Imamura, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

The mass food poisoning incident yusho occurred in Japan in 1968. It was caused by the ingestion of rice bran oil contaminated with polychlorinated biphenyls and various dioxins and dioxin-like compounds including polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDFs). Notably, PCDFs were found to contribute to approximately 65% of the total toxicity equivalent in the blood of yusho patients. Lipophilic dioxins are retained in the body for a longer period than previously estimated. Victims suffered from characteristic skin manifestations associated with non-specific systemic symptoms, neurological symptoms, and respiratory symptoms. The severe symptoms seen in the initial phase subsequently faded, but recently, improvements have scarcely been observed. The Yusho Group has been researching treatments for this condition. Several clinical trials with chelating agents or dietary fibers aimed at accelerating the excretion of compounds. While some treatments increased dioxin excretion, none provided satisfactory symptom relief. Concurrently, various phytochemicals and herbal extracts have been found to possess biological activities that suppress dioxin-induced toxicity via aryl hydrocarbon receptor or activate the antioxidant nuclear factor-erythroid 2-related factor-2 (NRF2) signal pathway, making them promising therapeutic candidates. Here, we summarize the current status of yusho and findings of clinical trials for yusho patients and discuss the treatment prospects.

元の言語英語
ページ(範囲)16472-16480
ページ数9
ジャーナルEnvironmental Science and Pollution Research
25
発行部数17
DOI
出版物ステータス出版済み - 6 1 2018

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Dioxins
dioxin
Toxicity
Chelation
Bioactivity
Antioxidants
Polychlorinated biphenyls
Skin
Blood
Hydrocarbons
PCDF
Clinical Trials
Skin Manifestations
Aryl Hydrocarbon Receptors
excretion
Foodborne Diseases
Polychlorinated Biphenyls
Dietary Fiber
Phytochemicals
Therapeutics

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

これを引用

Current state of yusho and prospects for therapeutic strategies. / Mitoma, Chikage; Uchi, Hiroshi; Tsukimori, Kiyomi; Todaka, Takashi; Kajiwara, Jumboku; Shimose, Takayuki; Akahane, Manabu; Imamura, Tomoaki; Furue, Masutaka.

:: Environmental Science and Pollution Research, 巻 25, 番号 17, 01.06.2018, p. 16472-16480.

研究成果: ジャーナルへの寄稿記事

Mitoma, C, Uchi, H, Tsukimori, K, Todaka, T, Kajiwara, J, Shimose, T, Akahane, M, Imamura, T & Furue, M 2018, 'Current state of yusho and prospects for therapeutic strategies', Environmental Science and Pollution Research, 巻. 25, 番号 17, pp. 16472-16480. https://doi.org/10.1007/s11356-017-0833-1
Mitoma C, Uchi H, Tsukimori K, Todaka T, Kajiwara J, Shimose T その他. Current state of yusho and prospects for therapeutic strategies. Environmental Science and Pollution Research. 2018 6 1;25(17):16472-16480. https://doi.org/10.1007/s11356-017-0833-1
Mitoma, Chikage ; Uchi, Hiroshi ; Tsukimori, Kiyomi ; Todaka, Takashi ; Kajiwara, Jumboku ; Shimose, Takayuki ; Akahane, Manabu ; Imamura, Tomoaki ; Furue, Masutaka. / Current state of yusho and prospects for therapeutic strategies. :: Environmental Science and Pollution Research. 2018 ; 巻 25, 番号 17. pp. 16472-16480.
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