抄録
The significance of neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) remains controversial with regard to the pathological response and long-term survival. We herein review the current status of and future perspectives regarding NACRT followed by esophagectomy for locally advanced ESCC. Some studies have suggested that a pathological complete response with NACRT is more common in patients with ESCC than in those with adenocarcinoma and that NACRT provided a survival benefit limited to patients with ESCC. However, NACRT may increase the risk of postoperative complications after esophagectomy. It is obvious that a favorable pathological response is the most important factor for obtaining a survival benefit, although no established parameters have been implemented clinically to predict the response to NACRT. Prospective clinical studies and basic research studies to identify predictive biomarkers for the response to NACRT are needed to aid in the development of NACRT treatment strategies for patients with ESCC.
元の言語 | 英語 |
---|---|
ページ(範囲) | 261-267 |
ページ数 | 7 |
ジャーナル | Surgery today |
巻 | 46 |
発行部数 | 3 |
DOI | |
出版物ステータス | 出版済み - 3 1 2016 |
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All Science Journal Classification (ASJC) codes
- Surgery
これを引用
Current status of and perspectives regarding neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. / Saeki, Hiroshi; Nakashima, Yuichiro; Zaitsu, Yoko; Tsuda, Yasuo; Kasagi, Yuta; Ando, Koji; Imamura, Yu; Ohgaki, Kippei; Ito, Shuhei; Kimura, Yasue; Egashira, Akinori; Oki, Eiji; Morita, Masaru; Maehara, Yoshihiko.
:: Surgery today, 巻 46, 番号 3, 01.03.2016, p. 261-267.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Current status of and perspectives regarding neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma
AU - Saeki, Hiroshi
AU - Nakashima, Yuichiro
AU - Zaitsu, Yoko
AU - Tsuda, Yasuo
AU - Kasagi, Yuta
AU - Ando, Koji
AU - Imamura, Yu
AU - Ohgaki, Kippei
AU - Ito, Shuhei
AU - Kimura, Yasue
AU - Egashira, Akinori
AU - Oki, Eiji
AU - Morita, Masaru
AU - Maehara, Yoshihiko
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The significance of neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) remains controversial with regard to the pathological response and long-term survival. We herein review the current status of and future perspectives regarding NACRT followed by esophagectomy for locally advanced ESCC. Some studies have suggested that a pathological complete response with NACRT is more common in patients with ESCC than in those with adenocarcinoma and that NACRT provided a survival benefit limited to patients with ESCC. However, NACRT may increase the risk of postoperative complications after esophagectomy. It is obvious that a favorable pathological response is the most important factor for obtaining a survival benefit, although no established parameters have been implemented clinically to predict the response to NACRT. Prospective clinical studies and basic research studies to identify predictive biomarkers for the response to NACRT are needed to aid in the development of NACRT treatment strategies for patients with ESCC.
AB - The significance of neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) remains controversial with regard to the pathological response and long-term survival. We herein review the current status of and future perspectives regarding NACRT followed by esophagectomy for locally advanced ESCC. Some studies have suggested that a pathological complete response with NACRT is more common in patients with ESCC than in those with adenocarcinoma and that NACRT provided a survival benefit limited to patients with ESCC. However, NACRT may increase the risk of postoperative complications after esophagectomy. It is obvious that a favorable pathological response is the most important factor for obtaining a survival benefit, although no established parameters have been implemented clinically to predict the response to NACRT. Prospective clinical studies and basic research studies to identify predictive biomarkers for the response to NACRT are needed to aid in the development of NACRT treatment strategies for patients with ESCC.
UR - http://www.scopus.com/inward/record.url?scp=84957426406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957426406&partnerID=8YFLogxK
U2 - 10.1007/s00595-015-1144-0
DO - 10.1007/s00595-015-1144-0
M3 - Review article
C2 - 25740123
AN - SCOPUS:84957426406
VL - 46
SP - 261
EP - 267
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 3
ER -