Current status of hematopoietic cell transplantation for adult patients with hematologic diseases and solid tumors in Japan

Masahiro Imamura, Shigetaka Asano, Mine Harada, Yasuo Ikeda, Koji Kato, Shunichi Kato, Keisei Kawa, Seiji Kojima, Yasuo Morishima, Yoshihisa Morishita, Tatsutoshi Nakahata, Jun Okamura, Shinichiro Okamoto, Shintaro Shiobara, Mitsune Tanimoto, Masahiro Tsuchida, Yoshiko Atsuta, Kazuhito Yamamoto, Junji Tanaka, Nobuyuki HamajimaYoshihisa Kodera

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

A nationwide survey of hematopoietic cell transplantation (HCT) was started in Japan in 1991, and the analyzed survey data have been presented as the annual report of the Japan Society for Hematopoietic Cell Transplantation. The 10-year overall survival (OS) rates after HCT for each disease are as follows: acute myelogenous leukemia, 44.2%; acute lymphocytic leukemia, 33.7%; adult T-cell leukemia, 24.6%; chronic myelogenous leukemia, 53.3%; myelodysplastic syndrome, 37.3%; non-Hodgkin's lymphoma, 41.5%; Hodgkin's lymphoma, 50.8%; aplastic anemia, 72.5%; breast cancer, 37.1%; germ cell tumor, 52.6%; and ovarian cancer, 44.2%.The 5-year OS rates for multiple myeloma and lung cancer were 40.6% and 23.6%, respectively. Except in cord blood transplantation, engraftment was accomplished in more than 90% of patients. The respective frequencies of acute graft-versus-host disease (GVHD) and chronic GVHD were 41.1% and 34.9% for related bone marrow transplantation (BMT), 66.8% and 34.5% for unrelated BMT, 52.9% and 36.0% for allogeneic peripheral blood stem cell transplantation, and 53.3% and 32.1% for allogeneic cord blood transplantation. OS for each disease was analyzed by patient age, stem cell source, donor type, disease status, and disease type. These data provide objective and valuable information for hematologists as well as for patients who need HCT.

本文言語英語
ページ(範囲)164-178
ページ数15
ジャーナルInternational journal of hematology
83
2
DOI
出版ステータス出版済み - 2 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学

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