Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis

Hiromichi Mitsuyasu, Yukiyoshi Yanagihara, Xiao Quan Mao, Pei Sun Gao, Yojiro Arinobu, Kenji Ihara, Akira Takabayashi, Toshiro Hara, Tadao Enomoto, Sei Sasaki, Minoru Kawai, Naotaka Hamasaki, Taro Shirakawa, Julian M. Hopkin, Kenji Izuhara

研究成果: ジャーナルへの寄稿記事

159 引用 (Scopus)

抄録

Two variant of the IL-4R α-chain (IL-4Rα) gene have been recently identified in association with different atopic disorders. To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Rα carrying either Val or Ile at 50 and either Gln or Arg at 551. The substitution of Ile for Val augmented STAT6 activation, proliferation, and transcription activity of the Iε promoter by IL-4, whereas that of Arg for Gln did not change these IL-4 signals. Arg551 was not associated with atopic asthma in the Japanese population. CD23 expression and IgE synthesis by IL-4 were augmented in Ile50-bearing PBMC, compared with those bearing Val50. Taken together, substitution of Arg551 does not enhance the IL-4 signal for generation of germline ε transcript, whereas the substitution of Ile50 contributes to enhancement of IgE synthesis.

元の言語英語
ページ(範囲)1227-1231
ページ数5
ジャーナルJournal of Immunology
162
発行部数3
出版物ステータス出版済み - 2 1 1999

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Interleukin-4 Receptors
Interleukin-4
Immunoglobulin E
Transcriptional Activation
Asthma
Population
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

Mitsuyasu, H., Yanagihara, Y., Mao, X. Q., Gao, P. S., Arinobu, Y., Ihara, K., ... Izuhara, K. (1999). Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis. Journal of Immunology, 162(3), 1227-1231.

Cutting edge : Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis. / Mitsuyasu, Hiromichi; Yanagihara, Yukiyoshi; Mao, Xiao Quan; Gao, Pei Sun; Arinobu, Yojiro; Ihara, Kenji; Takabayashi, Akira; Hara, Toshiro; Enomoto, Tadao; Sasaki, Sei; Kawai, Minoru; Hamasaki, Naotaka; Shirakawa, Taro; Hopkin, Julian M.; Izuhara, Kenji.

:: Journal of Immunology, 巻 162, 番号 3, 01.02.1999, p. 1227-1231.

研究成果: ジャーナルへの寄稿記事

Mitsuyasu, H, Yanagihara, Y, Mao, XQ, Gao, PS, Arinobu, Y, Ihara, K, Takabayashi, A, Hara, T, Enomoto, T, Sasaki, S, Kawai, M, Hamasaki, N, Shirakawa, T, Hopkin, JM & Izuhara, K 1999, 'Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis', Journal of Immunology, 巻. 162, 番号 3, pp. 1227-1231.
Mitsuyasu H, Yanagihara Y, Mao XQ, Gao PS, Arinobu Y, Ihara K その他. Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis. Journal of Immunology. 1999 2 1;162(3):1227-1231.
Mitsuyasu, Hiromichi ; Yanagihara, Yukiyoshi ; Mao, Xiao Quan ; Gao, Pei Sun ; Arinobu, Yojiro ; Ihara, Kenji ; Takabayashi, Akira ; Hara, Toshiro ; Enomoto, Tadao ; Sasaki, Sei ; Kawai, Minoru ; Hamasaki, Naotaka ; Shirakawa, Taro ; Hopkin, Julian M. ; Izuhara, Kenji. / Cutting edge : Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis. :: Journal of Immunology. 1999 ; 巻 162, 番号 3. pp. 1227-1231.
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abstract = "Two variant of the IL-4R α-chain (IL-4Rα) gene have been recently identified in association with different atopic disorders. To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Rα carrying either Val or Ile at 50 and either Gln or Arg at 551. The substitution of Ile for Val augmented STAT6 activation, proliferation, and transcription activity of the Iε promoter by IL-4, whereas that of Arg for Gln did not change these IL-4 signals. Arg551 was not associated with atopic asthma in the Japanese population. CD23 expression and IgE synthesis by IL-4 were augmented in Ile50-bearing PBMC, compared with those bearing Val50. Taken together, substitution of Arg551 does not enhance the IL-4 signal for generation of germline ε transcript, whereas the substitution of Ile50 contributes to enhancement of IgE synthesis.",
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AU - Mao, Xiao Quan

AU - Gao, Pei Sun

AU - Arinobu, Yojiro

AU - Ihara, Kenji

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AU - Enomoto, Tadao

AU - Sasaki, Sei

AU - Kawai, Minoru

AU - Hamasaki, Naotaka

AU - Shirakawa, Taro

AU - Hopkin, Julian M.

AU - Izuhara, Kenji

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