Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

Kazuya Shimoda, Kenjirou Kamesaki, Akihiko Numata, Kenichi Aoki, Tadashi Matsuda, Kenji Oritani, Sadafumi Tamiya, Kouji Kato, Ken Takase, Rie Imamura, Tetsuya Yamamoto, Toshihiro Miyamoto, Koji Nagafuji, Hisashi Gondo, Seiho Nagafuchi, Kei Ichi Nakayama, Mine Harada

研究成果: Contribution to journalArticle査読

48 被引用数 (Scopus)

抄録

IFN-α inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-α inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-α-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-α signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.

本文言語英語
ページ(範囲)4707-4711
ページ数5
ジャーナルJournal of Immunology
169
9
DOI
出版ステータス出版済み - 11 1 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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