Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

Peng Chen, Maki Ashida, Hisashi Doi, Yusuke Tsutsumi, Zenji Horita, Takao Hanawa

    研究成果: Contribution to journalArticle査読

    5 被引用数 (Scopus)

    抄録

    In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

    本文言語英語
    ページ(範囲)2020-2025
    ページ数6
    ジャーナルMaterials Transactions
    57
    12
    DOI
    出版ステータス出版済み - 2016

    All Science Journal Classification (ASJC) codes

    • 材料科学(全般)
    • 凝縮系物理学
    • 材料力学
    • 機械工学

    フィンガープリント

    「Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル